PAH News

August 7, 2019August 7, 2019

Phase 2a Trial of Rodatristat Ethyl, Potential Oral PAH Therapy, Begins Dosing

News, PAH News

A Phase 2a trial testing the potential oral treatment rodatristat ethyl in patients with pulmonary arterial hypertension (PAH) has begun dosing, its developer announced. Rodatristat ethyl (or RVT-1201), the ... Read more

July 31, 2019August 5, 2019

Better Risk Assessment Needed to Improve Care in PAH, International Survey Shows

News, PAH News

While physicians worldwide are conducting multi-parametric risk assessments to evaluate pulmonary arterial hypertension (PAH), they are not doing so to the extent recommended by current guidelines, results from an ... Read more

July 29, 2019July 29, 2019

Nintedanib Lowers Lung Blood Pressure in Rat Model of PAH, Study Shows

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Treatment with nintedanib lowered lung blood pressure in a rat model of pulmonary arterial hypertension by preventing cells of blood vessel walls from changing identity, and by inhibiting smooth ... Read more

July 26, 2019July 26, 2019

Specific Heart Rhythm Parameters Help Predict PH, Study Suggests

CTEPH News, News, PAH News, PH News

The heart rhythm of patients with pulmonary hypertension (PH) has limited ability to adjust to changes, compared to unaffected people used as controls in a new pilot study. The ... Read more

July 24, 2019July 24, 2019

Anti-inflammatory Diet Reduces Heart, Skeletal Muscle Changes in PAH Mice

News, PAH News

An anti-inflammatory diet with high amounts of protein, fish oil, the amino acid leucine, and oligosaccharides reduced changes in heart and skeletal muscle in a female mice model of ... Read more

July 18, 2019July 18, 2019

Long-term Orenitram Use Can Help PAH Patients Walk Longer Distances, Extension Trial Finds

News, PAH News

Long-term use of Orenitram led to moderate but durable, and dose dependent, improvements in exercise capacity in pulmonary arterial hypertension (PAH) patients, results from an open-label extension trial show. These findings ... Read more

July 17, 2019July 17, 2019

Raising Levels of Nur77 May Help Halt Progression of PH, Study Suggests

News, PAH News, PH News

Increasing levels of the receptor Nur77 in cells lining the blood vessels of patients with pulmonary hypertension (PH) may help halt progression of the disease by enhancing the signaling ... Read more

July 15, 2019July 15, 2019

Left Heart Dysfunction Plays Key Role in Severe PAH, Study Suggests

News, PAH News

Left heart dysfunction may play an important role in severe pulmonary arterial hypertension (PAH), and should be monitored to optimize treatment, according to new research. The study, “Impact of ... Read more

July 12, 2019July 12, 2019

Extracorporeal Life Support Helps iPAH Patients Needing Lung Transplant, but Outcomes Remain Poor

News, PAH News

Extracorporeal life support improves the lung performance of people with idiopathic pulmonary arterial hypertension (iPAH) who need a lung transplant. But patients usually enter the transplant list at advanced stages ... Read more

July 11, 2019July 11, 2019

Implantable CardioMEMS System Useful in Predicting Heart Failure Risk in PAH, Study Shows

News, PAH News

Abbott’s CardioMEMS HF system — a wireless heart failure monitor — can be safely used to monitor blood flow (hemodynamics) changes and help predict the risk of heart failure ... Read more

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