PH News

April 5, 2019April 5, 2019

LRP1 Protein Levels Linked to Blood Vessel Remodeling in PH, Study Suggests

News, PAH News, PH News

Increased levels of a protein called LRP1 may lead to blood vessel remodeling in pulmonary hypertension (PH) by causing changes in pulmonary artery cells that favor their proliferation, a ... Read more

March 29, 2019March 29, 2019

Certain Patients with Sarcoidosis-associated PH May Benefit from PH-specific Treatment, Real-world Study Suggests

News, PH News

Patients with sarcoidosis-associated pulmonary hypertension (SAPH) can improve their levels of a key biomarker after receiving specific treatment for PH, which suggests that PH-specific treatment may benefit this patient ... Read more

March 25, 2019April 4, 2019

Congenital Heart Defects May Lead to PH, Other Complications Later in Life, Expert Says

News, PH News

Heart defects that develop before birth may lead to a variety of complications later in life, including pulmonary hypertension (PH), according to cardiologist Sanjay Gandhi, MD. However, he says, it is ... Read more

March 22, 2019March 28, 2019

Polysplenia Syndrome a Risk Factor for Early PH, Study Suggests

News, PH News

People with polysplenia syndrome — a condition characterized by a “left-sidedness” on both sides of the body — have an increased risk for early development of pulmonary hypertension (PH), ... Read more

March 13, 2019March 13, 2019

1st Participant Enrolled in Phase 2 Trial of Levosimendan for PH Patients with Heart Failure

News, PH News

The first participant has been enrolled in a Phase 2 trial testing the investigational therapy levosimendan in pulmonary hypertension (PH) patients with heart failure and preserved ejection fraction (PH-HFpEF). Ejection ... Read more

March 7, 2019March 13, 2019

Study Identifies Factors that May Increase PH Risk After Atrial Septal Defect Repair

News, PH News

High pulmonary pressure, cardiac medication use, and poor heart function are all risk factors for pulmonary hypertension (PH) in adults after a procedure to repair an atrial septal defect, a ... Read more

March 6, 2019March 12, 2019

Transition from PDE5i to Adempas Without Washout Period Deemed Safe

CTEPH News, News, PAH News, PH News

Transition from phosphodiesterase-5 inhibitors (PDE5i) — such as United Therapeutics’ Adcirca (taladafil) and Pfizer‘s Revatio (sildenafil) — to Bayer‘s Adempas (riociguat), a soluble guanylate cyclase (sGC) stimulator, without a washout period ... Read more

March 4, 2019March 4, 2019

Children with IPH Have Similar Transplant Survival Rates as Those with Other Indications, Study Says

News, PH News

Children with idiopathic pulmonary hypertension (IPH) who underwent lung or combined heart-lung transplants show similar survival rates to children who underwent these procedures for other indications, according to a ... Read more

February 27, 2019March 5, 2019

Compound 3 Shows Promise in Relieving PH Disease Features, Study Says

News, PH News

Compound 3 is a potent and selective inhibitor of ROCK-1 and ROCK-2 — proteins associated with blood vessel contraction — and can ameliorate disease features of pulmonary hypertension (PH), a study ... Read more

February 25, 2019March 4, 2019

Revatio Treatment After Mitral Valve Surgery Found to Alleviate PH Symptoms

News, PH News

Treatment with Revatio (sildenafil) after surgery to the heart’s mitral valve significantly lowered pulmonary arterial pressure in patients with pre-operative significant pulmonary hypertension, researchers from Israel report. The study, “Sildenafil ... Read more

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