Capture more good days with Orenitram^® (treprostinil) extended-release tablets

Living with pulmonary arterial hypertension (PAH) can be a real challenge. You may be frustrated by symptoms such as shortness of breath or feeling tired, which can limit your participation in daily activities. And because PAH is a progressive disease, you may find yourself becoming less active over time.

Orenitram is proven to delay the progression of PAH and may help improve symptoms to help you do more and help control your PAH.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

Please see Important Safety Information for Orenitram at the end of this article.

“Taking Orenitram helps me have less shortness of breath.”
–An Orenitram patient

PAH at a glance

PAH symptoms can occur when the blood vessels inside your lungs become narrowed, making it harder for blood to flow. These changes are thought to be caused by imbalances of natural substances in 3 pathways in your body. There are medicines that treat each of those 3 pathways.

How does Orenitram work?

Orenitram works differently than other oral medications you may already be taking for your PAH. Orenitram mimics the effects of prostacyclin, a natural substance found in your body that opens up blood vessels so it’s easier for your heart to pump blood through your lungs.

Adding Orenitram may help make sure you don’t miss out on the benefits of treating your PAH with a prostacyclin medicine.

Why Orenitram?

What could Orenitram do for you? Learn more >

• 9 out of 10 patients improved or maintained their ability to do more daily activities with fewer symptoms, as measured by functional class*
• Decreased shortness of breath during daily activities*
• Reduced strain on their heart–that means your heart doesn’t have to work as hard to pump blood to your lungs*
• Increased their ability to walk farther, as measured by 6-minute walk distance test^†
• 9 out of 10 patients taking Orenitram either improved or maintained their risk status—and improvement was seen as early as 3 months*

“With Orenitram, I’m able to plan more and make more good memories. I can share even the simple things, like cooking or laughing, with my family and friends.”
–An Orenitram patient

Read what other patients have to say about Orenitram or watch videos featuring stories about their personal treatment journeys. Watch now >

Personalized dosing may offer you a long-term treatment option

Since PAH is a progressive disease, your treatment needs may change over time. With Orenitram, you
may not have to start a new medication. Your healthcare provider can continue to increase or change
your dose to meet your needs so you may be able to stay with Orenitram for the long term to help control your PAH.^‡

Low and slow to maximize therapeutic benefits

Orenitram is an oral tablet, usually taken 3 times a day with food.^§ Typically, your doctor will start you on Orenitram at a low dose (0.125 mg, 3 times daily)^|| and slowly increase it about once a week until you find what works for you. Slowly adjusting your dose over time is known as “titration.”

Learn how Luisa works with her healthcare team to get to her target dose and help manage side effects. Watch video >

How can higher doses help you reach your treatment goals?

In a clinical study, patients who achieved a dose of Orenitram of at least 3 mg, 3 times per day, were able to walk farther and had less shortness of breath after 24 weeks. That’s why it’s important to work with your healthcare provider to achieve a dose of Orenitram that will help you reach your treatment goals.

How Orenitram fits into your schedule

Orenitram should be taken with food, but keep in mind that you don’t have to eat a full meal. You can talk with your healthcare team about snack choices and combinations that may work best for you. Be sure to check out this interactive meal-planning tool for ideas.

For more information on Orenitram, talk to your healthcare provider or visit www.orenitram.com.

United Therapeutics offers a number of useful resources available for download.

Helpful links from United Therapeutics to learn more about Orenitram:

• Guide to understanding Orenitram
• Talking to your healthcare provider about Orenitram
• What to expect with Orenitram
• Guide to getting started with Orenitram
• Daily treatment journal and tracker

*In a clinical study that included 690 patients who were all taking a single oral PAH medicine (PDE-5i, sGCS, or ERA). At the beginning of the study, these patients added either Orenitram or placebo to their treatment.

^†In a clinical study that included 349 patients not taking any PAH therapy. At the beginning of the study, these patients began taking either Orenitram or placebo.

^‡There is no maximum dose for Orenitram, so your healthcare provider can continue to increase your dose as long as you are able to tolerate the medication.

^§Orenitram may also be taken 2 times a day (every 12 hours). Tablet strength may be increased depending on how well you tolerate treatment.

^||Starting dose may also be 0.25 mg, 2 times daily.

ERA=endothelin receptor antagonist; PDE-5i=phosphodiesterase type 5 inhibitor; sGCS=soluble guanylate cyclase stimulator.

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

• If you have liver problems or diverticulosis.
• If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
• About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin^® or Tyvaso^®.

How should I take Orenitram?

• Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
• Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
• Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
• If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
• If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
• If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
• You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

• Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
• The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
• Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

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