TYVASO DPI® (treprostinil) Inhalation Powder: As simple as OPEN, LOAD, INHALE

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by United Therapeutics |

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What are TYVASO and TYVASO DPI?

TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prescription medicines used in adults to treat:

  • Pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. TYVASO or TYVASO DPI can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking TYVASO or TYVASO DPI. It is not known if TYVASO or TYVASO DPI is safe and effective in children under 18 years of age.
  • Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), which is high blood pressure in the lungs due to inflammation and sometimes scarring in the lungs. TYVASO or TYVASO DPI can improve the ability to exercise.

TYVASO DPI fits in the palm of your hand

TYVASO® is now available in a Dry Powder Inhaler (DPI). This small, portable inhaler uses cartridges and features a simple-to-use design. Key features include:

  • Conveniently portable
  • Single-dose cartridges prefilled with medicine
  • Just 1 breath per cartridge, 4x daily

SELECTED IMPORTANT SAFETY INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)

Please see Important Safety Information for TYVASO and TYVASO DPI at the end of this article.

See how simple it is to use TYVASO DPI

Taking a dose is as simple as: JUST ONE BREATH – OPEN, LOAD, INHALE.

98% patient satisfaction rate with TYVASO DPI

TYVASO DPI received high satisfaction marks from 45 of 46 people in a clinical study who switched from the TYVASO nebulizer.

In the clinical study, 51 people with PAH who had been using the TYVASO nebulizer for at least 3 months switched to TYVASO DPI. Researchers recorded side effects, and after 3 weeks, patients rated their satisfaction with TYVASO DPI in a questionnaire.

Dosing with TYVASO DPI

Doses are taken in 1 breath per cartridge, 4x daily. Most patients use just 1 cartridge.

  • Available in a variety of cartridge strengths, which are color-coded to help you know which ones to take
  • Each dose is inhaled in less than 2 seconds

To learn more about TYVASO DPI, talk to your doctor or visit www.tyvaso.com/dpi

IMPORTANT SAFETY INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)
  • Are pregnant or plan to become pregnant. It is not known if either product will harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if either product passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Either product and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid®) or rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®)

What are the possible side effects of TYVASO or TYVASO DPI?

Both products can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, either product may lower your blood pressure more.
  • Bleeding problems. Either product may increase the risk of bleeding, especially in people who take blood thinners (anticoagulants).

The most common side effects of both products are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, diarrhea, and shortness of breath. Like other inhaled prostaglandins, you may have trouble breathing after taking TYVASO or TYVASO DPI because it may cause the muscles around your airway to tighten (bronchospasm). These are not all the possible side effects. Call your doctor for medical advice about side effects or if you have trouble breathing.

You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more about TYVASO or TYVASO DPI, talk with your healthcare provider. Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI™ Inhalation Powder, and additional information at www.TYVASO.com or call 1-877-UNITHER (1‑877‑864‑8437).

TYVISIconMAY2022

TYVASO and TYVASO DPI are registered trademarks of United Therapeutics Corporation.

All other brands are trademarks of their respective owners. The makers of these brands are not affiliated with and do not endorse United Therapeutics or its products.

© 2022 United Therapeutics Corporation. All rights reserved. US/TYV/0712

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