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Scientists have identified several genes that increase the risk of a person developing PAH. While mutations have been studied in adult-onset PAH, little has been known about mutations that cause cases in children.
A research team decided to remedy this. Their study included 155 children and 257 adults with PAH who had been treated at Columbia University over 22 years.
Participants were grouped according to how their disease originated. One group consisted of patients with the inherited form — familial, or FPAH. The other consisted of those with the non-genetic form — idiopathic, or IPAH.
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