Diogo Pinto,  —

Bellerophon Therapeutics has announced positive data from its Phase 3 clinical trial investigating INOpulse in patients with pulmonary arterial hypertension (PAH), as well as the enrollment of the first group of patients in its Phase 2b study testing INOpulse in patients with pulmonary hypertension associated with interstitial lung…

Aria CV, a company developing medical devices for pulmonary hypertension (PH), won the TCT 2018 Shark Tank Competition, a contest created to highlight the most innovative devices and technologies in the field of cardiovascular medicine. The announcement was made by the nonprofit research and educational organization Cardiovascular…

United Therapeutics and MannKind established a worldwide exclusive licensing and agreement to develop and commercialize a dry powder formulation of treprostinil, an approved vasodilator, for pulmonary arterial hypertension (PAH) that is now being tested along with the Technosphere inhalation device (a drug delivery system). The agreement gives…

Levosimendan, an investigational therapy for pulmonary hypertension associated with heart failure and preserved ejection fraction (PH-HFpEF), was found to improve workings of the kidneys in PH-HFpEF patients with kidney impairment in a Phase 3 clinical trial. Findings from the study, “Differential effects of levosimendan and dobutamine on glomerular…

Antidote Technologies, a digital health company, and phaware global association, an organization advocating for pulmonary hypertension (PH) awareness, will join forces to create a new recruitment system for pharmaceutical companies and contract research organizations (CROs) to enroll patients with chronic lung diseases in their clinical trials. The…

A man with pulmonary hypertension, the first international patient to receive an advanced but totally artificial heart known as the CARMAT heart, recently had a healthy donor heart successfully transplanted. The announcement, made by the National Research Center for Cardiac Surgery, in Astana, Kazakhstan, was confirmed by…

Women who have hypertension or preeclampsia, a more severe condition that leads to damage in the internal organs, during pregnancy have a two- to three-fold higher risk of developing hypertension later in life. Also, 70 percent of them have higher rates of type 2 diabetes and 30 percent have…

A type of extracorporeal membrane oxygenation (ECMO), a life support technique used to oxygenate the blood, was seen to significantly improve survival in end-stage pulmonary hypertension (PH) and interstitial lung disease (ILD) patients awaiting lung transplants, a retrospective study suggests. Researchers found that when performed in a venoarterial,…

Apelin, a peptide naturally produced in the body, reduces resistance in the pulmonary vascular system (blood vessels) and improves cardiac function in patients with pulmonary arterial hypertension (PAH), results from a clinical trial show. The therapy’s effects were even greater in patients also taking PAH medication, especially those on…

Intravenous infusions of treprostinil can improve disease severity in children with pulmonary hypertension (PH) associated with congenital diaphragmatic hernia (CDH), a birth defect that occurs when the diaphragm does not form properly, a new study shows. However, these babies have a greater likelihood of needing extracorporeal respiratory support,…

Acceleron Pharma, a biopharmaceutical company focused on rare diseases, has announced the start of the PULSAR Phase 2 clinical trial assessing the safety and effectiveness of sotatercept (ACE-011) in adults with pulmonary arterial hypertension (PAH). Sotatercept works by trapping members of the transforming growth factor-beta (TGF-beta) family, particularly those directly…

Clinical features of sarcoidosis-associated pulmonary hypertension are similar across patients in the U.S., Europe and Middle East, but treatment is more likely to be given to patients outside the United States, a study reports. These findings were drawn from data on 176 sarcoidosis-associated pulmonary hypertension (SAPH) patients enrolled in a…