An upcoming clinical trial will test whether empagliflozin, a drug widely approved to treat diabetes and heart failure, might be able to improve heart health in people with pulmonary arterial hypertension (PAH). The trial will be led by scientists at Cleveland Clinic, with study sites planned at two…
Long-term oxygen improves exercise capacity in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH), a study suggests. Twelve weeks of supplemental oxygen led to a significant and clinically relevant improvements in exercise capacity, as assessed with the six-minute walking distance test (6MWD), by 42…
A new device to deliver inhaled nitric oxide gas to newborns with pulmonary hypertension (PH), is now available for use in hospital neonatal intensive care units (NICUs) across the U.S. The rollout follows recent approval from the U.S. Food and Drug Administration of the next-generation device, the INOmax…
Exosomes, a type of small vesicle released by mesenchymal stem cells (MSCs), helped reduce vascular remodeling and ease pulmonary hypertension (PH) symptoms in a rat model of the disease, a study found. Exosome effects were tied to a modulation of the NF-kB/BMP pathway involved in vascular remodeling, a set…
Most adults with pulmonary arterial hypertension (PAH) who switched to Uptravi (selexipag) from other medications in its class achieved stabilization or a lessening of disease severity, according to an analysis of real-world treatment data from the SPHERE registry. Clinical outcomes were also generally good for Uptravi-treated PAH patients…
Liquidia has expanded a license agreement with Pharmosa Biopharm, acquiring rights to market L606, a potential inhaled formulation of treprostinil now in a Phase 3 study, across Europe, Japan, and other regions as well as in North America. The two-part and open-label Phase 3 clinical…
The use of selenium supplements — an essential mineral naturally present in many foods and added to others — reduced blood vessel remodeling, a hallmark of pulmonary arterial hypertension (PAH), in the lung, according to a new study. Selinium has antioxidant properties and may help protect cells from damage.
Cereno Scientific‘s investigational therapy CS1 was well tolerated and showed signs of clinical benefit in people with pulmonary arterial hypertension (PAH), according to top-line data from a Phase 2a clinical trial. The company plans to start discussions with regulatory authorities and will pursue a pivotal clinical trial to…
Elevated blood levels of uric acid are associated with a higher risk of pulmonary arterial hypertension (PAH) at the genetic level, a data study reported. “Overall, this study confirmed, from a genetic perspective, the causal relationship between serum UA [uric acid] levels and PAH,” the researchers wrote. They also…
Cereno Scientific’s investigational therapy CS014 was found to reverse remodeling, meaning alterations in structure and arrangement, of pulmonary arteries in a preclinical model of pulmonary arterial hypertension (PAH). According to the company, the new preclinical data “provide the most compelling evidence to date that CS014 offers a…
Differences in Uptravi (selexipag) maintenance doses have no impact on the risk of hospitalization among adults with pulmonary arterial hypertension (PAH), a real-world claims analysis suggests. While different maintenance doses did not affect treatment adherence or discontinuations among U.S. patients in the real world, dose adjustments were more…
Oral carnitine supplements were well tolerated and blood levels of the molecule increased in people with pulmonary arterial hypertension (PAH), a pilot study shows. Carnitine transports fatty acids — the building blocks of fatty molecules…
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