Reduced exercise capacity appeared to be a consequence of cardiac and pulmonary changes, but not skeletal muscle alterations, in rat…
Articles by Lindsey Shapiro, PhD
As of April 15, Opsynvi (macitentan and tadalafil) — the first single-tablet treatment combination approved by the U.S. Food…
Despite more women being affected by pulmonary hypertension (PH), men with the cardiovascular disease had worse right ventricular function…
The U.S. Food and Drug Administration (FDA) has approved once-daily, fixed-dose tablets containing a combination of macitentan and tadalafil —…
Higher blood levels of the sclerostin protein were linked to cardiac abnormalities and an elevated risk of pulmonary…
An investigational fixed-dose combination of macitentan and tadalafil in a single tablet (M/T STCT) led to improvements in…
Echocardiogram (ECG) measures that indicate the heart’s right ventricle (RV) and the pulmonary arteries are working poorly together…
A variant in the gene encoding the ALDH2 enzyme — fully known as aldehyde dehydrogenase 2 — was linked to…
While about a quarter of pulmonary arterial hypertension (PAH) patients treated with the investigational therapy sotatercept tested positive for…
Add-on treatment with sotatercept, an investigational therapy for pulmonary arterial hypertension (PAH) now under regulatory review in the…
Immune-related genes that could serve as potential therapeutic targets for pulmonary arterial hypertension (PAH) were identified in a recent…
An inhaled formulation of imatinib in development by Aerami Therapeutics to treat pulmonary arterial hypertension (PAH), was safe…