Margarida Maia, PhD,  science writer—

How chronic thromboembolic pulmonary hypertension (CTEPH) is managed across regions globally varies widely despite treatment advances, a survey study found, highlighting the need for more research, better guidelines, and ongoing education for healthcare providers. The study, “Treatment and management of chronic thromboembolic pulmonary hypertension (CTEPH): A…

Measuring blood vessel function in the arm in a noninvasive way can help predict pulmonary hypertension (PH) when combined with certain heart measurements, a study has found. The study, “Endothelial Function Correlates With Pulmonary Pressures in Subjects With Clinically Suspected Pulmonary Hypertension,” was published in The American Journal…

Sildenafil — a medication that relaxes blood vessels, thereby increasing blood flow — may possibly be used to treat neonatal pulmonary hypertension in babies born at high altitudes, where less oxygen is available for breathing. This is according to clinical observations by Alexandra Heath-Freudenthal, MD, a pediatric cardiologist, while…

Experts recommend taking Uptravi (selexipag) with food and slowly titrating it up, at a frequency of less than weekly or by raising one of the two daily doses, as tolerated, while caring for any side effects adults with pulmonary arterial hypertension (PAH) may be having. The recommendation came…

MACC1, a gene that’s been linked to overgrowth of cancer cells, is more active in the lungs of people with pulmonary arterial hypertension (PAH) than in healthy individuals, a study out of China found, suggesting it could be used as a diagnostic biomarker for the disease. Researchers also observed…

Note: This story was updated April 11, 2024, to remove reference to Acceleron Pharma, now a wholly owned subsidiary of Merck.  Winrevair (sotatercept-csrk), the under-the-skin injectable treatment recently approved in the U.S. for adults with pulmonary arterial hypertension (PAH), is expected to be available…

A slit lamp exam of the eyes may detect signs that could help doctors predict how well treatment will work in people with pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE), an autoimmune disease, a small study suggests. Specific eye signs can also help evaluate PAH progression…

Children with pulmonary arterial hypertension (PAH) who are started on treprostinil under the skin, or subcutaneously, at a younger age may be more likely to have better outcomes in the five years ahead, a study suggests. Starting before age 6, but not having an early response to treatment or…

Deaths around the world due to pulmonary hypertension (PH) have fallen over the past two decades, according to a new study, but 13 of the 54 countries included in the review actually saw their death rates rise. Worldwide, deaths from PH fell at an average rate of 3.2% each…

The hormone vasopressin may help improve oxygen levels and blood flow in newborns with acute pulmonary hypertension who fail to respond to treatment with inhaled nitric oxide, a study suggests. About two-thirds of newborns treated with vasopressin in the study, however, developed hyponatremia (a low level of sodium in…

A Phase 3 trial of an oral formulation of levosimendan, dubbed TNX-103, in people with pulmonary hypertension and heart failure with preserved ejection fraction (PH-HFpEF), has enrolled the first participant. LEVEL (NCT05983250) is recruiting up to 152 adults with PH-HFpEF, ages 18-85,…

Two genes were identified as potential drivers of pulmonary arterial hypertension (PAH) in a bioinformatics study, offering opportunities to better understand the disease and explore their use as biomarkers or therapeutic targets. The genes, called WDR43 and GNL2, were more active in the lungs of people with PAH than…