Author Archives: Patricia Inacio, PhD

Opsumit Shows Promise for Portopulmonary Hypertension in Phase 4 Trial

Treatment for 12 weeks with Actelion Pharmaceuticals’ Opsumit (macitentan) significantly improved blood vessels’ resistance in patients with portopulmonary hypertension without causing further damage to the liver, data from the PORTICO Phase 4 trial show. The study, “Macitentan for the treatment of portopulmonary hypertension (PORTICO): a multicentre, randomised, double-blind,…

AIT Therapeutics Secures $8M to Further its Nitric Oxide Delivery System for Respiratory Conditions

AIT Therapeutics has obtained a funding agreement that will raise $8 million through private investment in public equity (PIPE) financing to further development of its nitric oxide-based treatments for persistent pulmonary hypertension of the newborn, bronchiolitis, and nontuberculous mycobacteria. Nitric oxide (NO) is a strong vasodilator that opens blood vessels, and is…

Balloon Pulmonary Angioplasty Can Improve Survival of Patients with Inoperable CTEPH, Study Suggests

Survival rates of patients with chronic thromboembolic pulmonary hypertension (CTEPH) unable to undergo surgical treatment have significantly improved in recent years, a retrospective study has found. This suggests that minimally invasive balloon pulmonary angioplasty and other interventions implemented more recently can improve CTEPH patients’ prognoses. The study, “Predictors…

Poor Heart Function Raises Risk of Early Death After Lung Transplant for IPAH Patients, Study Suggests

Certain parameters of poor heart function are risk factors for early death among idiopathic pulmonary arterial hypertension (IPAH) patients who undergo lung transplant, a small Chinese study suggests. The study, “Risk Analysis of Perioperative Death in Lung Transplant Patients With Severe Idiopathic Pulmonary Hypertension,” was published in the journal…

NT-proBNP Levels Can Predict Long-term Outcomes and Treatment Response in PAH Patients, Study Says

Levels of NT-proBNP can predict long-term outcomes and response to treatment with Uptravi (selexipag) in patients with pulmonary arterial hypertension (PAH), a post-hoc analysis of the Phase 3 GRIPHON trial shows. The study, “Association of NT-proBNP and Long-Term Outcome in Patients with Pulmonary Arterial Hypertension: Insights from the Phase III…