Santiago Gisler,  —

Balloon pulmonary angioplasty reduces sleep apnea in chronic thromboembolic pulmonary hypertension (CTEPH) patients, according to a study. The observed improvements further correlated with a better mean pulmonary arterial pressure. The results from the study, “Balloon pulmonary angioplasty attenuates sleep apnea in patients with chronic thromboembolic pulmonary hypertension,” was…

INOmax (nitric oxide) gas improved the oxygenation of premature, term, and near-term newborns with pulmonary hypertension (PH) and associated hypoxic respiratory failure, according to data from a interim analysis of Mallinckrodt Pharmaceuticals’ Phase 4, observational PaTTerN registry study. Persistent PH in newborns occurs when the pressure in…

Upon treatment with inhaled nitric oxide, oxygenation improved faster in preterm, near-term, and term newborns with hypoxic respiratory failure and pulmonary hypertension (PH), a Japanese study shows. The registry-based study, “An Analysis of Time to Improvement in Oxygenation in Japanese Preterm and Late Preterm or Term Neonates with…

Patients with pulmonary hypertension (PH) living in the U.K. experience delayed diagnosis, which has important implications for their financial and emotional status, according to a survey conducted by the Pulmonary Hypertension Association UK (PHA-UK). The results were described in an article, titled…

The U.S. Food and Drug Administration (FDA) has agreed to change the ongoing Phase 2b study  evaluating INOpulse in patients with pulmonary hypertension (PH) associated with interstitial lung disease (PH-ILD) into a Phase 2/3 clinical trial, the therapy’s manufacturer, Bellerophon Therapeutics, announced. With this decision the agency also agreed to change the…

Systemic hypertension is an independent predictor in rare cases of pulmonary arterial hypertension (PAH) associated with systemic lupus erythematosus (SLE), a retrospective large-cohort study in Taiwan shows. According to the findings, most of the observed PAH cases occurred within five years of SLE diagnosis. The study, “Incidence and…

The pharmaceutical company Sandoz announced the commercialization of an injectable form of the vasodilating therapy treprostinil for treating exercise-related symptoms affecting individuals with pulmonary arterial hypertension (PAH). This treprostinil injection is the first generic substitute (the non-branded version of a developed therapy) of Remodulin, developed and sold…

Resverlogix announced that it has received funding from the Canadian Institutes for Health Research for a Phase 2 clinical study investigating the safety and efficacy of its proprietary therapy apabetalone (RVX-208) as a potential treatment for pulmonary arterial hypertension (PAH). Resverlogix will match the new funding, including in-kind…

A Phase 3 clinical trial testing LIQ861 met its primary objective, showing that the investigational inhaled dry powder treprostinil formulation is safe and effective for the treatment of pulmonary arterial hypertension (PAH), according to clinical biopharmaceutical company Liquidia Technologies. Liquidia’s LIQ861 is an alternative to the current inhaled treprostinil treatment…

Compound 3 is a potent and selective inhibitor of ROCK-1 and ROCK-2 — proteins associated with blood vessel contraction — and can ameliorate disease features of pulmonary hypertension (PH), a study finds. The study “Pharmacological characterization of a highly selective Rho kinase (ROCK) inhibitor and its therapeutic effects in experimental…

The American Thoracic Society (ATS) has published new recommendations for home oxygen therapy to treat chronic hypoxemia (low oxygen levels in the blood) in children with chronic lung or pulmonary vascular diseases, including pulmonary hypertension (PH). The guidelines were published in the American Journal of Respiratory and Critical…

High levels of cardiac troponin in the blood of pulmonary hypertension (PH) patients are associated with a poorer prognosis, according to a study. The meta-analysis study, “Serum Cardiac Troponin Elevation Predicts Mortality in Patients with Pulmonary Hypertension: A Meta‐Analysis of 8 Cohort Studies,” was published in The…