News

‘PH Care for All’ Campaign Targets Poor and Minorities in U.S. Whose Pulmonary Hypertension Often Goes Untreated

The Pulmonary Hypertension Association (PHA) announced the launch of “PH Care for All,” an initiative to address disparities in the treatment of pulmonary hypertension (PH) among minorities and low-income patients in the United States, and led by 26 highly regarded PH specialists. “With fourteen treatments — which is as many or more…

Step Up for PHAwareness on World Pulmonary Hypertension Day May 5

On May 5, more than 80 organizations around the world will participate in activities designed to raise awareness of this often-misdiagnosed disease and to celebrate the lives of people living with what is called pulmonary hypertension (PH), or pulmonary arterial hypertension (PAH) — a condition of high blood pressure in…

Praxair’s Inhaled Nitric Oxide Therapy for Newborns with Pulmonary Hypertension Approved in Canada

Praxair, Inc., announced that it has received approval, through a subsidiary, for the sale of its Noxivent brand of inhaled nitric oxide in Canada. Noxivent is indicated for the treatment of newborns, including some born prematurely, suffering respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension (PH). PH in neonates can…

Right Ventricle Enlargement Successfully Treated in PAH Animal Model Using Ranolazine, a Heart Drug

Researchers from Chungbuk National University, Korea, found that ranolazine (Ranexa), a drug used to treat coronary heart disease, effectively reduced the structural remodeling of the heart’s right ventricle in an animal model of pulmonary arterial hypertension (PAH). The results suggested that targeting right ventricle disease could delay PAH progression in people.

Right Ventricle Dysfunction in PAH May Be Treated by Drug Targeting a Signaling Pathway Independent of Arterial Pressure

Blocking the enzyme sphingosine kinase 1 (SK1) reduced right ventricle enlargement in a mouse model of pulmonary arterial hypertension (PAH), while having no impact on blood vessel remodeling. The findings, published in the journal Cellular Signalling, highlighted disease mechanisms potentially crucial for future drug development. Scientists have…

Karos Advancing Its Small Molecule Drug Candidate to Treat PAH, KAR5585, in Clinical Testing

Karos Pharmaceuticals announced that is advancing its small molecule drug candidate, KAR5585, in clinical testing as a treatment for pulmonary arterial hypertension (PAH) and other rare diseases characterized by fibrosis. A number of agents have recently been introduced as therapeutic drugs for PAH. Among them, KAR5585 is a first-in-class, selective inhibitor of an enzyme…

Balloon Angioplasty Seen to Benefit People with Inoperable CTEPH and Other Conditions, Too

Balloon pulmonary angioplasty (BPA) appears to be of multiple benefit to patients with chronic thromboembolic pulmonary hypertension (CTEPH), both in terms of hemodynamics and in other systemic disorders like glycemic control and kidney disease, according to a study published in the journal Circulation, titled “Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients…

Pulmonary Fibrosis Foundation Enrolls 1st Person in PFF Patient Registry, a Research Tool

The Pulmonary Fibrosis Foundation (PFF) announced it has enrolled its first pulmonary fibrosis (PF) patient in the newly launched PFF Patient Registry, a collaborative effort involving patients, researchers, and healthcare providers that will gather data to advance PF research and improve patients’ quality of life. Enrollment takes place at participating PFF Care Center Network (CCN) sites across the…