INOpulse, a nitric oxide delivery device that is being developed by Bellerophon Therapeutics, was approved by health authorities in Belgium to be used in a Phase 2 trial in patients with pulmonary hypertension associated with chronic obstructive pulmonary disease (PH-COPD). The first patient is expected to be enrolled in the third quarter…
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Mitochondria in lung arteries responds in an opposite way to a lack of oxygen compared to mitochondria in other parts of the body, as they constrict and remodel blood vessels. This finding allowed researchers to reverse pulmonary hypertension in rats by transplanting mitochondria from a leg artery to the lung by…
Chinese researchers have identified a microRNA as a key molecular factor involved in lung blood vessel remodeling in response to low oxygen levels — a process leading to pulmonary hypertension. The study “Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via…
Many people living with Pulmonary Hypertension are on a no- to low-sodium diet. But trying to keep to such a diet can be very challenging, and create obstacles for dining with friends, even for preparing your own meals. People with PH are advised to maintain a low-sodium diet because salt can cause…
The Pulmonary Hypertension Association (PHA) recently accredited the University of Rochester (UR) Medical Center as a Comprehensive Care Center, recognizing its excellence in research, diagnosis, and clinical care for patients with pulmonary hypertension (PH). The group’s PH Care Centers (PHCC) initiative provides accreditation to centers with expertise in PH, particularly pulmonary arterial…
Drugs that suppress the immune system should be used together with drugs that dilate the arteries, to treat pulmonary arterial hypertension (PAH) associated with adult-onset Still’s disease (AOSD) according to a new study published in the journal Respiratory Medicine Case Reports.
In recent years, reports emerged linking diabetes to pulmonary hypertension. But news that a disease affecting our blood sugar could increase the risk, or speed the progression, of a devastating lung disease is difficult to imagine. A recent review attempts an explanation. Titled “The Role of Hyperglycemia and…
Eiger BioPharmaceuticals recently reported the dosing of a first patient in its Phase 2 LIBERTY clinical trial, evaluating the effects of ubenimex (Bestatin) as an add-on therapy to current standard of care in patients with pulmonary arterial hypertension (PAH). The study is currently recruiting adult patients with PAH WHO…
Pulmonary hypertension can be detected using echocardiography earlier than previously thought according to a new study conducted on newborn mice.
The presence of atrial arrhythmias may help predict unfavorable prognosis in patients with pulmonary hypertension (PH), according to a study published in the Cardiology Journal. The study also showed that longer P-waves, a type of wave found in electrocardiographies (ECG), can predict shorter survival rates. The work was developed…
Mifcare, a Paris-based biotechnology company recently announced positive pre-clinical results for their compound MFC1040.
Screening the gene transcripts of both people with pulmonary arterial hypertension and several PAH animal models, researchers at Mie University Graduate School of Medicine in Japan identified a new gene that might contribute to the disease. The findings, published in the journal Frontiers in Pharmacology under the title…
