Measuring the levels of an inflammatory protein known as HMGB1 may help diagnose persistent pulmonary hypertension of the newborn (PPHN) and monitor its progression, according to a study in patients and in a rat model. The research, “High mobility group box 1 protein (HMGB1) as biomarker…
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Loss of a hormone called secretin (SCT) induces hypertension, scarring, and structural alterations in the heart and lungs, a study in mice reports. The study “Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice” was published in the journal Nature Scientific Reports, and…
Oral treatment with rodatristat ethyl is safe and well-tolerated, according to results from two completed Phase 1 clinical studies in healthy volunteers. These positive results support advancing the investigational therapy into Phase 2 studies involving people with pulmonary arterial hypertension (PAH), the treatment’s developer says. The most recent…
Halting a protein called Slug may help reduce the severity of increased blood pressure related to lung scarring — a condition called pulmonary hypertension (PH) secondary to pulmonary fibrosis, or PF-PH, a new animal study shows. The study, “Histological hallmarks and role of Slug/PIP axis…
An enzyme involved in DNA damage processes, called EYA3, contributes to structural changes in lung blood vessels and to the progression of pulmonary hypertension (PH), according to a study in patient-derived cells and in rats. These findings also suggest that blocking EYA3 could be an effective treatment for people…
The Pulmonary Hypertension Association (PHA) has named Loma Linda University Health California’s first accredited pulmonary hypertension (PH) medical center. Loma Linda is now one of the nation’s 12 accredited regional clinical programs, as established by the association’s PH Care Center initiative to raise the overall quality of care…
Patients with pulmonary arterial hypertension (PAH) who carry a specific mutation in the RNF213 gene have poor clinical outcomes and worse response to combination treatments, according to a study from Japan. The study, “Poor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial…
The incidence of pulmonary arterial hypertension (PAH) is rare in France, but it carries a high economic burden, a new study showed. The data were reported in “Hospital Burden of Pulmonary Arterial Hypertension in France,” a study published in the journal PLOS ONE. Economic studies on the…
Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, D.C., couldn’t come at a better time, says Marshall Summar, MD, chairman of NORD’s board of directors. “The pace of discovery in rare diseases has gone from brisk to hypersonic,” Summar told Bionews Services, publisher…
Analysis of a North American pediatric registry revealed significant variability of pulmonary hypertension (PH) subtypes among children of different racial and ethnic groups, with reduced survival rates among black children with lung disease-associated PH, a new study reports. The study, “Racial…
V-Wave’s new interatrial shunt — a medical device designed to reduce arterial heart pressure — has been granted breakthrough device designation by the U.S. Food and Drug Administration (FDA) for the treatment of people…
Translate Bio is focusing its efforts on the development of new therapies targeting pulmonary diseases, including pulmonary arterial hypertension and cystic fibrosis, among others. In light of this, the company is discontinuing the development of its lead candidate MRT5201 for ornithine transcarbamylase deficiency — a metabolic…
