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BET Proteins Potential Therapy Target for COPD Patients with PH
Inhibition of proteins that regulate gene expression — called BET — were found to ease pulmonary hypertension (PH) in a rat model of chronic obstructive pulmonary disease (COPD), a study reports. PH is characterized by changes in the small pulmonary arteries that increase the resistance to blood flow and lead to hypertrophy, or enlargement, of the heart’s right ventricle.
Scientists believe that in COPD patients, who have a higher incidence of PH than the general population, blood vessel alterations could result from chronic hypoxia — lack of sufficient oxygen — as well as inflammation. Click here to learn more.
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