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Let’s Discuss The Metabolic Basis of Pulmonary Arterial Hypertension
@valerie would like to challenge us to a complex topic based on two articles she read regarding mast cells and the metabolic basis of PH. She is hoping someone in our forums has some knowledge about this and would like to discuss.
Valerie shared the following:
In addition to the symptoms associated with PH, I have other symptoms (for example, migraine, intolerance to many foods, foci in the brain of unknown origin, etc.). I thought that these symptoms are signs of other diseases. I’ve seen doctors who should understand these symptoms. But doctors are narrow specialists. They offer a lot of medicines and examinations, but all this is in the narrow field of medicine.
I began to read a lot of books and articles on medicine, and then on biochemistry. And now I have come to important conclusions regarding PH. I read about the effect on the PH of mast cells (mast cells play a key role in the inflammatory process). It turns out that Paul Ehrlich wrote about the accumulation of mast cells around the lungs in people with PH back in 1879. You can read the article here.
Then I delved even more into the topic of cells and found another article which you can read here. In the blood of patients with PH, the level of inflammatory and immune cells is increased (we discussed elevated red blood cells here, but people with PH have other signs of inflammation for sure). PH is a syndrome involving many internal organs of a person. And the main disease is the malfunction of the cells (if I understand correctly. The article says a lot about mitochondria, but it is difficult to understand). People with PH also have problems with skeletal muscles, right ventricle, spleen, and bone marrow. Mitochondria work somehow incorrectly, and the immune system tends to correct the body’s work and makes it even worse. Many of us are prescribed phosphodiesterase type 5 inhibitors and similar medications that do not affect the pathology of the disease.
From what Valerie read the metabolic PH theory explains many of the symptoms (these symptoms were thought to be unrelated to PH).
She understands that this is a very complex topic but is hoping someone might know a bit about it or is interested in the research. Please share your knowledge and thoughts.
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