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Let’s Discuss The Metabolic Basis of Pulmonary Arterial Hypertension
- This topic has 12 replies, 3 voices, and was last updated 3 months, 2 weeks ago by Jen Cueva.
March 31, 2021 at 2:40 pm #29575
@valerie would like to challenge us to a complex topic based on two articles she read regarding mast cells and the metabolic basis of PH. She is hoping someone in our forums has some knowledge about this and would like to discuss.
Valerie shared the following:
In addition to the symptoms associated with PH, I have other symptoms (for example, migraine, intolerance to many foods, foci in the brain of unknown origin, etc.). I thought that these symptoms are signs of other diseases. I’ve seen doctors who should understand these symptoms. But doctors are narrow specialists. They offer a lot of medicines and examinations, but all this is in the narrow field of medicine.
I began to read a lot of books and articles on medicine, and then on biochemistry. And now I have come to important conclusions regarding PH. I read about the effect on the PH of mast cells (mast cells play a key role in the inflammatory process). It turns out that Paul Ehrlich wrote about the accumulation of mast cells around the lungs in people with PH back in 1879. You can read the article here.
Then I delved even more into the topic of cells and found another article which you can read here. In the blood of patients with PH, the level of inflammatory and immune cells is increased (we discussed elevated red blood cells here, but people with PH have other signs of inflammation for sure). PH is a syndrome involving many internal organs of a person. And the main disease is the malfunction of the cells (if I understand correctly. The article says a lot about mitochondria, but it is difficult to understand). People with PH also have problems with skeletal muscles, right ventricle, spleen, and bone marrow. Mitochondria work somehow incorrectly, and the immune system tends to correct the body’s work and makes it even worse. Many of us are prescribed phosphodiesterase type 5 inhibitors and similar medications that do not affect the pathology of the disease.
From what Valerie read the metabolic PH theory explains many of the symptoms (these symptoms were thought to be unrelated to PH).
She understands that this is a very complex topic but is hoping someone might know a bit about it or is interested in the research. Please share your knowledge and thoughts.
April 7, 2021 at 10:38 am #29624
I love this, @valerie! I want to read a bit more about this research. The last neurologist I saw mentioned metabolic syndrome to me. I am quite interested and will save this to read as I have more time and process my thoughts to share afterward.
It is crazy how a “lung” disease affects so much more, and I don’t think they still know what areas are affected by PH and how other symptoms once thought to be idiopathic are actually part of PH. Thanks for this conversation starter.
April 7, 2021 at 5:46 pm #29631
@s-steppins let me know if you are still having problems responding to this topic. I know Valerie would appreciate hearing what you have to share about it.
April 8, 2021 at 11:10 am #29638
I read the articles, and I must say this is quite interesting to me. I had a PHriend for a short time who was also an MD. They thought that she had PH for some time. She did her own research and found that she did not have PH, but she had mitochondrial dysfunction.
She was telling me that to be sure that I have this ruled out because some of the symptoms and cell formation were similar in both PH and MD. I mentioned this to my PH doc then, and they said I definitely had PH, but he agreed that some had MD, too. I had not read any more about this until now.
April 15, 2021 at 1:20 pm #29758
Thank you all for responding!
I know I’ve brought up a difficult topic. Jen, thanks for the link, I haven’t heard of” Mitochondrial Diseases ” yet. I will definitely read about it. Your friend is very cool! When we look for answers, we become real detectives!
Colleen, do you know that Susi knows something about this topic? It would be very nice to hear her opinion. Every piece of evidence is important in this case ????
April 15, 2021 at 3:26 pm #29767
Hi @valeriekv, No problem. I enjoy learning while helping others when I can. Nothing is too difficult here. Post your thoughts and questions at any time. That is how we learn and help one another.
How are you feeling?
April 15, 2021 at 3:33 pm #29769
@valeriekv Susi was having technical issues posting but to this topic but I don’t know what she had to share about it. @s-steppins if you still can’t post to this private message me what you want to share and I will post it for you…then reach out to tech again for help.
February 6, 2023 at 11:13 am #37259
Hey, y’all, I wanted to share a link that may be helpful for those interested in reading more about metabolic disorders and how they can relate to PH.
This article was shared in Advances in Pulmonary Hypertension in 2021. You can read more here.
@valeriekv, I haven’t seen any posts by post in some time. How are you doing?
February 7, 2023 at 11:42 am #37274
A very interesting article. I think this information is intended for those people who got LH not at birth, but later. But this article proves again that everything is interconnected in the human body. Last year I visited many different doctors and only two of them believe that everything is interconnected in the body. Thank you for not rejecting this idea.
I’m sorry, I’ve been missing for a while. In the fall, I was unable to log in to my account. Apparently some work was being done on the site.
I am currently struggling with the side effects of multiple sclerosis medication. I still can’t see well and get very tired. My saturation is rarely above 80%. I’m thinking about buying a stationary oxygen concentrator because of this.
February 8, 2023 at 12:23 pm #37284
Yes, thank you @jenc for sharing this informative article!
@valeriekv it’s so good to hear from you but I’m concerned to hear how much you are struggling with your health. Hopefully your doctor can request a stationary concentrator so that it will hopefully be covered or at least partially by insurance.
We are here for you through the ups and downs so please feel free to reach out any time!
I’m sorry you were having problems logging in to the forums. Hopefully that won’t happen again but if it does you can email me at [email protected]
February 8, 2023 at 2:23 pm #37288
Hi @valeriekv, I’m sorry about your continued struggles with your MS treatment and oxygen sats. As @colleensteele mentions, wouldn’t this be covered by your insurance or medicare? Either way, you will need an order from your medical team, correct?
Yes, you are right, Valerie everything is interconnected inside our bodies. For those physicians who think otherwise, I question.
Please email either @colleensteele or me if you have any issues logging in anytime. I know this can be frustrating, so we apologize for the inconvenience. My email is [email protected]. This is for anyone who has tech issues, too.
We are here to support you and worry when you aren’t posting. Take care of yourself.
February 9, 2023 at 10:34 am #37306
Hi, @colleensteele, Hi, @jenc!
Thank you for your kindness! It’s very nice.
We don’t have any insurance or similar things. If I buy an oxygen concentrator, then I will buy it at the store. Now I have a small aerosol can with oxygen for emergencies (when I have very low saturation).
Thank you for sharing your email addresses! This may be necessary. Even now, sometimes I need to take the “I’m not a robot” test. This test is driving me crazy ????
Have you ever noticed the connection between metabolism and PH? At least, I often find anti-gluten recommendations in articles about diets for various diseases (autoimmune diseases and PH). Apparently, scientists associate gluten with inflammation.
February 10, 2023 at 12:04 pm #37327
Hi @valeriekv, I also struggle with proving I’m human at times. Those things are always very sensitive; however, most websites are using that now to keep spammers away. You’re not the only one who struggles with this, hehe.
I do think PH and metabolism are related. Because it’s vascular and in our cells, this would be connected to our metabolic system, is my thinking. Like you, I read articles and medical journals and often read that these two are connected. We learn fast that our bodies are interlinked much more than we ever thought, right?
I will share some things in our Diet and Nutrition forum that you may find helpful if you’ve missed them. Yes, anti-inflammatory foods do much more than typical medical treatments in some instances.
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