18 Medications That Can Cause Pulmonary Hypertension


The use of certain prescription medications and street drugs can lead to the development of pulmonary hypertension. Here’s a list of drugs that have been linked to the onset of the disease according to the Pulmonary Hypertension Association of Canada.

Weight Loss Medications 

Weight loss medications or appetite suppressants have been linked to pulmonary hypertension. These include:

  • Aminorex
  • Dexfenfluramine (Redux)
  • Fenfluramine (Ponderal, Pondimin)
  • Phentermine (Ionamin)
  • Mazindol


Chemotherapy is used to treat cancer and some autoimmune diseases such as lupus. Chemotherapy medications that could increase the risk of developing pulmonary hypertension include:

  • Bleomycin
  • Busulfan
  • Carmustine (BCNU)
  • Dasatinib
  • Interferon-alpha
  • Interleukin-2
  • Lomustine (CCNU)
  • Mitomycin C
  • Nitrosoureas

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Street Drugs

Abuse of street drugs (or recreational drugs) may also increase the risk of a person developing pulmonary hypertension. In particular, the following drugs:

  • Amphetamine
  • Cocaine
  • Methamphetamine

Other Medicines

A type of amino acid commonly used to treat disorders such as sleep apnea and depression may also increase the risk of pulmonary hypertension:

  • L-tryptophan

MORE: How oxygen therapy helps with pulmonary hypertension

Pulmonary Hypertension News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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  1. Hala says:

    My doughter 14 years old was diagnosed with GIA currently she is taking anakinra injections 100 mg cyclosporine 100mg and cycliphophamide 500mg evey 2weeks recently she develops pulmonary hypertension. Any of that drugs ( interaction ) can be the cause ??

  2. G Brogan says:

    I am concerned as I had been taking Bronkaid (25mg ephedrine) several times a week as a diet aid. Now I am concerned about long term consequences. What are the risks of Pulmonary Hypertension due to this OTC medication?

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