Marisa Wexler, MS, senior science writer —

Marisa holds a Master of Science in cellular and molecular pathology from the University of Pittsburgh, where she studied novel genetic drivers of ovarian cancer. Her areas of expertise include cancer biology, immunology, and genetics, and she has worked as a science writing and communications intern for the Genetics Society of America.

Articles by Marisa Wexler

PAH linked to methamphetamine use tied to worse heart health

People with pulmonary arterial hypertension (PAH) related to use of methamphetamine — a potent stimulant only legally available by prescription — tend to have worse heart health and poorer exercise capacity compared with patients with other forms of PAH. That’s according to a new study, “Methamphetamine-associated…

SPHK2 protein may offer way to reverse pulmonary hypertension

A protein called SPHK2 helps to drive pulmonary hypertension (PH) by changing the epigenetic profiles of cells in blood vessels, a study reports. Epigenetics refers to changes in gene activity that do not change the genetic code itself. As such, study findings imply that blocking SPHK2 or otherwise reversing…

Results from Phase 2b part of inhaled imatinib trial due in June

The Phase 2b portion of the IMPAHCT clinical trial, which is testing multiple doses of the inhaled imatinib formulation AV-101 against a placebo in adults with pulmonary arterial hypertension (PAH), has finished enrollment. Top-line results are expected in June 2024, according to AV-101’s developer, Aerovate Therapeutics. “The completion…

FDA decision on sotatercept for PAH expected in March

The U.S. Food and Drug Administration (FDA) has agreed to review an application seeking approval of sotatercept as a treatment for adults with pulmonary arterial hypertension (PAH). The FDA has given the application priority review, shortening the review time from the usual 10 months to six months. A decision…

Approval decision on Yutrepia for PH-ILD expected in January

Note: This story was updated Jan. 30, 2024, to correct the approved indications of available treprostinil formulations. Amid ongoing litigation, the U.S. Food and Drug Administration (FDA) has agreed to review an application from Liquidia that seeks to extend the approval of Yutrepia — an inhaled dry powder…

Experimental therapy targets PAH-driving serotonin receptor

Treatment with VU6047534, an experimental therapy that blocks the activity of a specific type of serotonin receptor, reduced strain on the heart in a mouse model of pulmonary arterial hypertension (PAH) in a new study. The study, “Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment…

Sotatercept improves blood flow, heart health in PAH: STELLAR trial

Treatment with sotatercept in addition to standard pulmonary arterial hypertension (PAH) therapies significantly improved measures of heart health for adults with the disease, according to a new analysis of the STELLAR trial. Results from the Phase 3 trial had already shown the therapy enhanced walking abilities in the participants…


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