Marisa Wexler, MS, senior science writer —

Marisa holds a Master of Science in cellular and molecular pathology from the University of Pittsburgh, where she studied novel genetic drivers of ovarian cancer. Her areas of expertise include cancer biology, immunology, and genetics, and she has worked as a science writing and communications intern for the Genetics Society of America.

Articles by Marisa Wexler

Sildenafil better than bosentan for newborns with PPHN: Study

Sildenafil is generally more effective than bosentan at controlling blood pressure and reducing the need for supplemental oxygen in infants with persistent pulmonary hypertension of the newborn (PPHN), a study shows. The study, “Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn:…

Phase 2 trial of TX45 for PH-HFpEF beginning to enroll patients

A Phase 2 clinical trial of TX45, Tectonic Therapeutic’s investigational therapy for pulmonary hypertension and heart failure with preserved ejection fraction (PH-HFpEF), has begun enrolling eligible patients. The Phase 2 study, called APEX (NCT06616974), is expected to recruit up to 180 adults with PH-HFpEF, ages…

Prostacyclins show promise as CTEPH treatment: Meta-analysis

Treatments that target the prostacyclin pathway hold promise as chronic thromboembolic pulmonary hypertension (CTEPH) treatment for patients who aren’t eligible for surgery, but more data is needed to verify the effectiveness of these medications in this type of pulmonary hypertension, according to the authors of a meta-analysis of…

Macitentan-tadalafil combination therapy effective in PAH: Analysis

For people with pulmonary arterial hypertension (PAH) both with and without a few co-occurring heart problems, combination therapy with macitentan and tadalafil is similarly effective, according to a new analysis by researchers in the U.S. and Europe. “Initial combination therapy with macitentan plus tadalafil is efficacious in patients with…

FDA paves way for Phase 2 study of TX45 in PH-HFpEF patients

The U.S. Food and Drug Administration has given Tectonic Therapeutic the go-ahead to start a Phase 2 clinical trial of TX45, the company’s experimental treatment for pulmonary hypertension and heart failure with preserved ejection fraction (PH-HFpEF). “We remain enthusiastic about the potential of TX45 to address the…

EU committee recommends combo tablet Yuvanci be approved for PAH

A committee of the European Medicines Agency (EMA) has recommended that Yuvanci, a tablet containing macitentan and tadalafil, be approved for pulmonary arterial hypertension (PAH). The positive opinion from the EMA’s Committee for Medicinal Products for Human Use (CHMP) specifically recommends Yuvanci be approved for PAH in individuals with…