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The U.S. District Court for the District of New Jersey has ruled in United Therapeutics Corporation‘s favor in the company’s case against Sandoz, regarding United Therapeutics’ Remodulin product. First approved in the United States in May 2002, Remodulin is a prostacyclin vasodilator used for the treatment of pulmonary arterial…

The first results of AMBITION, a large pulmonary arterial hypertension clinical trial, will be presented this month at the European Respiratory Society (ERS) International Congress 2014, as part of the highlights of the meeting. AMBITION is a randomized, double blind, multi center Phase 4 clinical trial testing the efficacy…

Sorrento Therapeutics, Inc., a late-stage clinical oncology company, has announced that it will advance with its immunotherapy targeting WNT1-Inducible Signaling Protein-1 (WISP1) for the potential treatment of idiopathic pulmonary fibrosis (IPF). IPF is a chronic and fatal disease that occurs in individuals between 50 and 70 years of…

UCLA researchers have shown that oxidized lipids may contribute to pulmonary hypertension (PH), a progressive and incurable disease that is responsible for narrowing the small blood vessels in the lungs. In a study entitled “Apolipoprotein A-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p”…

A group of researchers from the University of Pécs, Hungary, have attempted to understand the mechanism by which pulmonary vascular remodeling initiates right ventricular failure and hypoxia, one of the leading causes behind the mortality rates associated with Pulmonary Hypertension (PH). Sildenafil, known more commonly by its…

Although clinically unexplored, pulmonary hypertension (PH) in the setting of idiopathic pulmonary fibrosis (IPF) is a significant reality in many patients (32 to 85%). IPF is an irreversible disease in which progressive loss of lung function due to fibrosis occurs, diminishing the lung’s capacity to absorb oxygen…

Systemic sclerosis (SSc) is a disease that affects multiple organs, with the heart being frequently affected and correlating with a poor outcome for the patient. Different heart structures can be affected leading to pericardial disease, arrhythmias, conduction system abnormalities, direct myocardial disease such as pulmonary arterial hypertension, myositis, cardiac failure,…

GeNo LLC, a pharmaceutical company developing a line of innovative nitric oxide drug products, is currently testing next-generation inhaled nitric oxide (NO) drug delivery systems for use in both hospital and outpatient settings that could come to impact treatments for those with pulmonary hypertension. Nitric oxide is a naturally…

A team of researchers from the University Medical Center Groningen in Holland, has identified three baseline variables that can become treatment goals in children suffering with pulmonary arterial hypertension (PAH). PAH is rare in infants, however, it is a severe condition that rapidly deteriorates if left untreated.

A team of researchers from the Imperial College London, UK, has preformed a three-dimensional speckle tracking (3D-ST) study and found that patients who have pulmonary hypertension (PH) are found to suffer from reduced right ventricular (RV) strain and notably more dyssynchronous ventricles compared to healthy individuals. 3D-ST is an…

A team of researchers has published their results assessing left atrial volume in chronic thromboembolic pulmonary hypertension (CTEPH) patients before and after pulmonary thromboendarterectomy (PTE), a surgical procedure that removes organized, clotted blood from the pulmonary arteries. When the body cannot reabsorb a pulmonary embolism (PE), clots…

Expert medical specialty care for rare diseases like pulmonary arterial hypertension was recently the subject of review in an article by Sean M. Studer, MD, MS, Chief of Medicine, Woodhull Hospital Medical Center, NY. The article, entitled “Do Patients With Pulmonary Arterial Hypertension Benefit From Referral to…