Ana Pena, PhD,  —

Women with pulmonary arterial hypertension (PAH) secondary to congenital heart disease (PAH-CHD) are at a high risk of heart failure, pulmonary hypertensive crisis, or even death during pregnancy, a study reports. Those at a higher risk appeared to be women with…

The heart’s ventricular mass may be an early prognostic biomarker for predicting the risk of heart failure and death in people with pulmonary arterial hypertension (PAH), a recent study suggests. The research, “Ventricular mass…

Variations in a gene called FIGN predispose to familial or heritable pulmonary arterial hypertension (FPAH) in carriers of the p.Arg491Gln mutation at the BMPR2 gene, according to a study looking at the largest family known to date with a history of the disease. The findings may help to advance understanding…

Heart defects that develop before birth may lead to a variety of complications later in life, including pulmonary hypertension (PH), according to cardiologist Sanjay Gandhi, MD. However, he says, it is still not possible to predict if or when these complications will arise. Congenital heart defects (CHDs) occur when the…

Women’s pulmonary artery muscle cells produce more of a signal molecule called hypoxia-inducible factor 1-alpha (HIF1α), which may contribute to the higher prevalence of pulmonary arterial hypertension (PAH) in women compared to men, a study reports. The data also suggest that a component of…

Spouses of people with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) report feeling insecure about their situation and dissatisfied with the degree of information and support provided by healthcare teams, according to…

United Therapeutics has now acquired worldwide rights over ralinepag, a potential oral medication under Phase 2 and 3 clinical testing for pulmonary arterial hypertension (PAH), the company announced in a press release…

Biotechnology company Morphogen-IX has raised $23.2 million to advance development of its lead drug candidate, MGX292, for the treatment of pulmonary arterial hypertension (PAH). The investment, led by Medicxi with contributions from …

Switching treatment from United Therapeutics’ Tyvaso (inhaled treprostinil) to Actelion’s Uptravi (oral selexipag) is safe and considered convenient by patients with…

Revatio (sildenafil) in low doses is safe and can be of benefit to children with pulmonary hypertension (PH), particularly those with early lung disease, a study reports. With this work, the researchers weighed in on a controversy, coming down in favor of the treatment. Revatio is approved to treat adults with pulmonary…

Treprostinil is a therapy that works to reduce pulmonary artery narrowing in people with pulmonary arterial hypertension (PAH) by preventing artery wall remodeling processes. That finding comes from a research study investigating the medicine’s molecular effects using patient lung artery cells suggests. Treprostinil appears to…

Liquidia Technologies has completed the enrollment for the safety part of a Phase 3 trial evaluating the safety and tolerability of LIQ861, an inhaled dry power formulation of treprostinil for the treatment of pulmonary arterial hypertension…