Marisa Wexler, MS, senior science writer —

The outcomes used in clinical trials of pulmonary arterial hypertension (PAH) don’t fully reflect the priorities of patients and clinicians, a new study asserts. The study, “‘It’s that invisible illness’: Patient and clinician perspectives on outcomes in pulmonary arterial hypertension treatment,” was published in the journal…

Janssen Pharmaceuticals has submitted an application to the U.S. Food and Drug Administration (FDA) seeking approval of a combination tablet containing both macitentan and tadalafil as a treatment for pulmonary arterial hypertension (PAH). “People with PAH are often prescribed numerous medicines to manage their condition, so the potential…

Treatment with AER-901, an inhaled formulation of imatinib that Aerami Therapeutics is developing as a treatment for two forms of pulmonary hypertension, was generally well-tolerated in a Phase 1 study conducted with healthy volunteers. That’s according to safety data presented by Aerami at the 2023 American Thoracic Society…

Treatment with KER-012, an experimental therapy Keros Therapeutics is developing to treat pulmonary arterial hypertension (PAH), lowered markers of heart damage, fibrosis, and inflammation in a Phase 1 clinical trial that tested the therapy in healthy postmenopausal women. Keros presented the findings at the American Thoracic Society (ATS)…

The proportion of people with pulmonary arterial hypertension (PAH) who start on a combination of medications after they’re diagnosed is low, but has increased over the last decade, a study shows. The findings were presented at the 2023 American Thoracic Society (ATS) International Conference, in the poster, “…

Gossamer Bio is planning to soon launch a Phase 3 clinical trial to test its experimental inhaled therapy seralutinib (GB002) in people with pulmonary arterial hypertension (PAH). “We remain on track to begin our Phase 3 clinical trial of seralutinib in the coming months, moving one step closer…

Many people with pulmonary arterial hypertension (PAH) report better mental and physical health following the start of the COVID-19 pandemic, a study found. “Unexpectedly, we found that some objective measures of pulmonary hypertension disease severity actually improved during the COVID-19 pandemic. This included longer 6-minute walk distances, lower NT-proBNP…

Balloon pulmonary angioplasty, or BPA, can be an effective treatment for chronic thromboembolic pulmonary hypertension (CTEPH), a new study highlights. “Patients treated with BPA experienced improvement in functional class and exercise capabilities, with relatively low rates of procedure-related complications,” researchers wrote. The study, “Refined Balloon Pulmonary…

Statistical models using U.S. insurance data can help to predict the risk of hospitalization within one year of starting on treatment among people with pulmonary arterial hypertension (PAH), scientists report. Identified risk factors for pulmonary hypertension-related hospitalization included female sex, shortness of breath, and…

Measuring blood levels of three molecules — SAM, guanine, and NT-proBNP — could help identify pulmonary arterial hypertension (PAH) in children with congenital heart diseases (CHD), a study suggests. “This 3-marker panel has the potential to be used in clinical practice for the early diagnosis and screening of PAH-CHD,”…

A noninvasive measure of heart and blood vessel function called the TAPSE/PASP ratio could help prioritize people with pulmonary arterial hypertension (PAH) who may benefit most from a lung transplant, according to a new study. “We demonstrated that the echocardiographic index of TAPSE/PASP … was lower in patients who…

Treatment with Pulnovo Medical’s pulmonary artery denervation (PADN) device significantly reduced the risk of clinical worsening among people with pulmonary arterial hypertension (PAH) in a clinical trial, according to new data announced by the company. Chen Shaoliang, a professor at Nanjing First Hospital of Nanjing Medical University in China,…