A novel dual endothelin receptor antagonist (ERA), Macitentan, (manufactured by Actelion pharmaceuticals) had been approved for use against Pulmonary Arterial Hypertension (PAH) by the US FDA in October 2013. This came shortly after Actelion Pharma presented the results of its landmark clinical trial SERAPHIN (Study with Endothelin Receptor Antagonist…
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) has been identified as one of the major causes of acute pulmonary hypertension (PH). This condition is characterized by a progressively dangerous accumulation of blood clots within pulmonary vasculature, which leads to PH and can eventually cause right-sided heart failure. It…
Hypoxia is the clinical manifestation of loss of oxygen supply in the body, leading to difficulty in breathing. Alveolar hypoxia can cause constriction of the distal pulmonary arterioles, which leads to increased arterial pressure and pulmonary arterial hypertension (PAH). This is a common condition among people living in high altitudes,…
Maxim Petrichuk / Shutterstock.com PoppyPocket founder and CEO, Julie Hydzu, has just announced her commitment to backing women’s cycling team PHenomenal Hope in an upcoming cross-country race dedicated to raising awareness on pulmonary hypertension and gathering funds for the Pulmonary Hypertension Association (PHA). It will be…
Pulmonary Hypertension (PH) is a rare condition characterized by increased pressure and constriction of the pulmonary arteries and the surrounding veins, which in turn applies excess pressure to the right side of the heart. It is a progressive condition that worsens with time if left untreated. The…
A novel concept of targeting the autonomic nervous system around pulmonary arteries and activation of vasointestinal peptides (VIP) to treat Idiopathic Pulmonary Arterial Hypertension (IPAH) was recently developed by a group of researchers. The study, published in the online journal Therapeutics and Clinical Risk Management (March 27, 2014), profiled a 58…
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