Researchers have identified distinct genetic changes tied to the severity of idiopathic pulmonary arterial hypertension (IPAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Data showed that the expression (activity) of the ABCA3 gene was lower in IPAH patients, while that of the SMAD9 gene was increased in CTEPH, particularly…
Treatment with anticoagulants, also known as blood thinners, does not extend survival in people with pulmonary arterial hypertension (PAH), according to a large French study. These findings were supported by an additional pooled analysis of published studies involving more than 2,000 PAH patients, researchers found. “From the most rigorous…
Global death rates and levels of disability among newborns with pulmonary arterial hypertension (PAH) have declined since 1990, while the incidence of new cases has remained stable, according to a 30-year analysis. Still, mortality and disability rates are disproportionately higher in countries with low economic status, “underscoring the critical…
Researchers used computer-based modeling to develop a measure, called pulmonary vascular compromise (PVC), which estimates the reduced function of the pulmonary blood vessels in children with pulmonary arterial hypertension (PAH), according to a study. Supported by clinical data, a higher PVC, meaning a loss of the pulmonary vasculature, was…
A new sequential strategy successfully treats people with severe chronic thromboembolic pulmonary hypertension (CTEPH), significantly reducing high blood pressure and improving heart function, a study finds. The three-step regimen — medication, balloon pulmonary angioplasty (BPA), and pulmonary endarterectomy (PEA) surgery — is designed for people facing unacceptably high surgical…
Winrevair (sotatercept-csrk), when added to standard of care, reduced clinical worsening events by 76% in adults recently diagnosed with pulmonary arterial hypertension (PAH). That’s according to now-published data from the Phase 3 HYPERION (NCT04811092) clinical trial, which evaluated …
Stem cell-derived conditioned medium, or the liquid that remains after cells are cultured, reduces the signs of pulmonary arterial hypertension (PAH) in rat and cell models, a study showed. “These findings support [stem cell]‐derived conditioned medium as a promising therapeutic strategy for PAH, warranting further investigation in translational studies…
Phaware, a global advocacy organization, is launching a special podcast series to raise awareness of pulmonary arterial hypertension (PAH) caused by the use of methamphetamine, a stimulant drug known for its psychoactive effects. Methamphetamine-induced PAH is now known simply as Meth-PAH. The six-episode series, part of the “…
People with pulmonary hypertension (PH) face significant obstacles when seeking timely care, with barriers arising at each stage from symptom onset through diagnosis and treatment, according to interviews with patients and healthcare providers. Those barriers included a lack of PH knowledge among non-specialists, symptoms being dismissed, and limited access…
Tectonic Therapeutic plans to launch a Phase 2 clinical trial to test the impact of its therapy candidate TX45 on blood flow, or hemodynamics, in people with pulmonary hypertension and interstitial lung disease (PH-ILD). The move comes on the heels of positive results from part A of a…
Having pulmonary hypertension (PH) increases the risk of death, both in the short and long term, for individuals undergoing surgery for the heart valve disease aortic stenosis, a new analysis of published studies has found. Noting the older age, generally, of people with aortic stenosis undergoing the procedure, the…
People with pulmonary arterial hypertension (PAH) with at least one coexisting condition associated with cardiovascular disease had similar rates of hospitalization and mortality as those without these conditions after a combination treatment of macitentan and tadalafil, according to a real-world analysis. There was, however, a tendency towards more adverse…
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