Author Archives: Steve Bryson PhD

Long Noncoding RNAs May Have Role in PH Onset, Rat Study Finds

Seven long noncoding RNA molecules were found to be associated with the development of pulmonary hypertension (PH) in an early study in rats, scientists reported. The researchers noted that some of these RNAs are known to regulate immune and inflammatory response pathways, which may participate in PH. “Our study…

Early CTEPH Diagnosis Linked to Key Benefits, ‘Acceptable’ Costs

Using a healthcare cost model, researchers in the Netherlands found that an early diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) leads to substantial life expectancy and quality of life benefits at an “acceptable” price. Although greater healthcare costs were associated with an earlier diagnosis — primarily due to the…

Rare Inherited Mutations Shown to Cause Severe Childhood PAH

Rare mutations in the ATP13A3 gene caused a severe inherited form of childhood-onset pulmonary arterial hypertension (PAH), a case study of three families showed. These findings demonstrate the “growing importance” of genetic testing in patients with childhood-onset PAH, the scientists said, noting that the genetic basis of the disease…

FDA Grants Orphan Drug Status to Inhaled Imatinib Formulation

AER-901, an inhaled formulation of imatinib being developed as a treatment for pulmonary arterial hypertension (PAH), has been granted orphan drug designation by the U.S. Food and Drug Administration (FDA). The investigational therapy was designed with the goal of reducing the side effects reported among PAH patients using an…

Routine, Non-Invasive Tests May Predict PH Severity, Mortality

Routine blood screenings and non-invasive clinical tests may predict disease severity and mortality in people with pulmonary hypertension (PH), a study suggested. Specifically, the red blood cell distribution width (RDW) test, used in hematology laboratories to classify anemia, may help in assessing disease severity, while electrocardiographic ratios may predict…

PH Not Common Disease, Population Study Finds, But Groups at Risk

The likelihood of developing pulmonary hypertension (PH) is low among people in southern Italy, a study drawn from a random and large grouping of individuals with echocardiograms, done to determine disease prevalence, suggested. Independent predictors of PH include female sex and right ventricular enlargement, its scientists noted. The study, “…