News

Karos Reports Positive Safety Data from Phase 1 Trials of PAH Therapy

Karos Pharmaceuticals, a start-up focused on the selective modulation of peripheral serotonin synthesis, recently reported positive results from its Phase 1 clinical trials evaluating KAR5585, a compound being developed to treat orphan diseases such as pulmonary arterial hypertension (PAH) and carcinoid syndrome. KAR5585 is a first-in-class, selective inhibitor of tryptophan hydroxylase…

Bayer and CVN Award Research Fellowships to 2 Pulmonary Hypertension Specialists

Bayer and the Canadian Vascular Network (CVN) recently announced the winners of a joint research fellowship that provides recognition and financial support to outstanding Canadian physician-researchers with an academic interest in pulmonary hypertension (PH). The recipients are Dr. Jason Weatherland, a respirologist and clinical assistant professor at the University…

Swiss Approve Uptravi as Treatment for Pulmonary Arterial Hypertension

Actelion Pharmaceuticals recently announced that Swissmedic, the Swiss regulatory agency for therapeutic products, has approved the orally active, selective IP prostacyclin-receptor agonist Uptravi (selexipag) for the treatment of pulmonary arterial hypertension (PAH). Uptravi is indicated for the treatment of PAH in patients with advanced functional limitation (NYHA-functional class III/IV) to…

Babies with Down Syndrome May Be at Risk of PAH Before Birth

During their development, babies who will be born with Down syndrome have higher levels of anti-angiogenic factors in their lungs, impairing fetal lung vessel growth and potentially contributing to their developing pulmonary arterial hypertension (PAH), researchers report. The study, “Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in…

Reata Releases Update on Clinical Program, Including Phase 2 Study in PH and PAH Patients

Reata Pharmaceuticals recently provided an update on its clinical candidates and their developmental, including its Phase 2 proof-of-concept studies into bardoxolone methyl as a potential treatment for various types of pulmonary hypertension and omaveloxolone for neuromuscular diseases. Bardoxolone methyl is being developed for patients with pulmonary arterial hypertension (PAH), or high…

Low-risk PAH Patients May Be Able to Switch from Parenteral to Oral Therapies

Low-risk pulmonary arterial hypertension (PAH) patients may be able to switch from pump-infusion parenteral prostacyclin therapy to more convenient oral therapies, according to the study, “Transition from parenteral to oral treprostinil in pulmonary arterial hypertension,” published in the Journal of Heart and Lung Transplantation. Prostanoids, which include prostaglandins, thromboxanes and prostacyclins,…