Apollo Therapeutics has approved £8.5 million ($10.6 million) to fund four projects, including a small and large molecule discovery program to treat pulmonary arterial hypertension (PAH). Professors Martin Wilkins and Lan Zhao of Imperial College London‘s Department of Medicine will head the PAH program. Both have previously identified a gene called…
The rapid growth of smooth muscle cells in pulmonary arteries causes vasoconstriction and pulmonary arterial hypertension (PAH). Now, researchers found that the same drugs that inhibit cancer cell growth may also be effective in treating PAH. The study, “Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial…
Meticulous observation and aggressive treatment, together with long-term hospital stay and a multidisciplinary approach resulted in a successful pregnancy and delivery in a woman with pulmonary arterial hypertension (PAH), as reported by a case study published in the journal Tanaffos.
Patients with pulmonary arterial hypertension (PAH) have low levels of low-density lipoprotein cholesterol (LDL-C) – or “bad cholesterol” – which is associated with an increased mortality risk, according to a new study. PAH treatment may increase LDL-C levels. The study, “Low-Density Lipoprotein Cholesterol And Survival In Pulmonary Arterial Hypertension,”…
A patient treated with chemotherapy and radiation after breast cancer surgery developed pulmonary hypertension and other heart complications, according to a case study. Researchers called for doctors to watch for patients at high risk of heart damage due to cancer therapy, and recommended echocardiography for the detection of such cases. The…
The medication Adempas (riociguat) effectively improves several hemodynamic parameters in patients with pulmonary arterial hypertension (PAH), according to the Phase 3 PATENT-1 clinical trial. Results showed that the drug improved these parameters — which included pulmonary vascular resistance (PVR), right atrial pressure (RAP) and cardiac index — not only in PAH…
The European Medicines Agency (EMA) is reviewing the safety of Uptravi (selexipag) after the deaths of five patients with pulmonary arterial hypertension (PAH) who took the medicine in France. The European Union approved Uptravi for the treatment of PAH in May 2016. The EMA’s Pharmacovigilance Risk Assessment Committee (PRAC) will re-examine all…
The approved multiple-sclerosis treatment Tecfidera was seen to improve pulmonary arterial hypertension (PAH) and inhibit lung fibrosis in mice by targeting multiple signaling pathways in a recent study. The research, “Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways,” was published in the journal…
Terrence Jenkins, second-year celebrity ambassador of the Pulmonary Hypertension Association (PHA), will appear in a print and digital public service ad campaign throughout 2017 to raise awareness about pulmonary hypertension (PH). Jenkins, better known as “Terrence J,” knows firsthand some of the frustrations of battling a rare disease like…
Training with an oscillatory whole-body vibration (WBV) device may improve the exercise capacity, physical performance and quality of life of patients with pulmonary arterial hypertension (PAH), according to results of a new trial. The findings were published in an article titled “Oscillatory Whole-Body Vibration Improves Exercise Capacity And Physical Performance…
Dave Merryman, a researcher at Tennessee’s Vanderbilt University, has received $6 million to develop new treatments for pulmonary hypertension and other heart diseases. His research focuses on drugs initially intended to treat rheumatoid arthritis, and knowledge from failures of weight-loss drugs. Merryman, an associate professor of biomedical engineering, is currently developing treatments for heart…
A cohort study with Chinese patients identified systemic sclerosis (SSc) as the key underlying disease that significantly worsens the clinical outcomes of patients with pulmonary arterial hypertension (PAH). The study “Clinical characteristics and survival of pulmonary arterial hypertension associated with three major connective tissue diseases: A cohort study in…
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