Posts by: Alice Melão

Alice Melão

June 6, 2018June 6, 2018

Protein That Works to Regulate Blood Vessel Contraction May Lead to Better Hypertension Therapies, Study Suggests

News, PAH News, PH News

A molecular mechanism involving the tight balance between two proteins — Gal-1 and CaV1.2 — was found to regulate the behavior of blood vessel cells, directly contributing to hypertension. ... Read more

May 20, 2018May 30, 2018

EU Grants $2.91M to ATXA Therapeutics for Development of NTP42, Investigational PAH Therapy

News, PAH News

Horizon 2020, the European Union’s prestigious research and innovation program, recently awarded ATXA Therapeutics €2.5 million ($2.91 million) to support the development of ATXA’s lead therapy candidate NTP42 and help ... Read more

May 16, 2018May 16, 2018

Scottish Agency Recommends Uptravi for PAH Treatment Through National Health System

News, PAH News, PH News

Scottish patients with pulmonary arterial hypertension (PAH) can now be treated with Actelion‘s Uptravi (selexipag) through the country’s National Health System (NHS) after a positive recommendation from the Scottish Medicines ... Read more

May 14, 2018May 14, 2018

Reata Recruiting More CTD-PAH Patients for Phase 3 CATALYST Trial Testing Bardoxolone Methyl

News, PAH News, PH News

Reata Pharmaceuticals is currently recruiting participants for its Phase 3 CATALYST trial assessing the effectiveness of bardoxolone methyl in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH). After analysis of ... Read more

May 7, 2018May 7, 2018

Blocking FoxM1 Gene Seen to Prevent Vascular Remodeling and PH Progression in Mice

News, PH News

A gene called FoxM1 was seen to be an important regulator of the vascular remodeling process involved in pulmonary hypertension. It triggers the proliferation of smooth muscle cells in ... Read more

April 25, 2018

Surgical Repair of Congenital Heart Defects Improves Survival in PAH Patients, Study Shows

News

Surgery to repair congenital heart defects leads to longer survival in patients with pulmonary arterial hypertension (PAH) caused by heart disease, according to researchers. This finding was reported in ... Read more

April 16, 2018April 16, 2018

Protein That Regulates Calcium Could Become Target for PAH Therapy, Study Reports

News, PAH News

University of Edinburgh researchers identifying a protein that could become a target for treating pulmonary arterial hypertension, or PAH. They discovered that the two-pore segment channel 2 protein, or TPC2, in ... Read more

April 12, 2018April 12, 2018

Genetic Landscape of PAH Differs Between Children and Adults, Study Shows

News, PAH News

The genetic landscape of pulmonary arterial hypertension that strikes in childhood differs from the one that develops after a person reaches adulthood, a study reports. There is little variation ... Read more

March 29, 2018March 29, 2018

Researchers Reveal Critical Role of KLF15 Protein in Pulmonary Hypertension

News, PH News

A protein called KLF15 has an important protective role in the lung, according to the findings of Johns Hopkins researchers. KLF15 was found to be a critical regulator of ... Read more

March 19, 2018March 19, 2018

Bellerophon Is Advancing Its PH Treatment INOpulse Through Clinical Trials

News, PAH News, PH News

Bellerophon Therapeutics is advancing the clinical trials program of its inhaled INOpulse nitric oxide therapy for pulmonary hypertension (PH) associated with several lung diseases. The company is developing INOpulse for patients ... Read more

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