News

Bosentan Improved Endothelial Function in PAH, but Not in CTEPH Patients, Study Finds

Researchers at the Nagoya University Graduate School of Medicine in Japan demonstrated that the endothelin receptor antagonist bosentan can improve endothelial dysfunction parameters in patients with pulmonary arterial hypertension (PAH), but not in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). The findings were published in the Pulmonary…

PAH Patient Survival may be Predicted by Plasma Levels of Two Lipid Metabolites

Researchers from Tufts Medical Center in Boston identified two new biomarkers that may help predict survival in patients with pulmonary arterial hypertension (PAH). Findings from the study “Plasma 12- and 15-hydroxyeicosanoids are predictors of survival in pulmonary arterial hypertension,” were recently published in the journal Pulmonary Circulation. PAH…

PAH Study Reveals Unexpected Genetic Complexity

Mutations in the ENG gene might contribute to disease mechanisms in pulmonary arterial hypertension (PAH), according to a recent study demonstrating that PAH patients often carry ENG gene changes in addition to other, more well-studied mutations. The study demonstrates that genetic contributions to PAH are more complex than anticipated, raising the…

Screening Rheumatoid Arthritis Patients for PAH May Be Relevant

Rheumatoid arthritis patients may be at greater risk for pulmonary arterial hypertension (PAH), and noninvasive screenings for PAH could identify the risk, offering a chance for treatment at early stages, according to recent findings from the University of Newcastle in Australia. The link between PAH and systemic sclerosis has long been accepted,…

Galectin-3 Inhibitors Show Positive Preclinical Results for PAH Vascular Remodeling

Galectin Therapeutics recently announced that GR-MD-02, its galectin-3 (gal-3) inhibitor in development-stage, has shown a positive effect on vascular remodeling in an animal model of pulmonary arterial hypertension (PAH). Galectin proteins are key mediators of biologic function. The announcement was made during a poster presentation of the company’s preclinical results at…

PAH Progression Linked to MicroRNA, Offering Potential Drug Target

Researchers at England’s University of Sheffield have identified a microRNA that, when lacking in patients, appears to be driving the progression of pulmonary arterial hypertension (PAH). The findings, identifying potential new drug targets, open up avenues of research that might lead to better treatments for this fatal disease. “This research opens…