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PAH Review Finds Combination Therapy Superior to Monotherapy in Reducing Clinical Worsening

The use of a combination therapy in patients with pulmonary arterial hypertension (PAH) “significantly” reduced the risk of clinical worsening compared to monotherapy in those responding to treatment, according to a recent meta-analysis published in the journal The Lancet, titled “Combination therapy versus monotherapy for pulmonary arterial hypertension:…

Hypothyroidism, a Thyroid Condition, Found in Almost Half of IPH Patients in Study

Researchers recently investigated the link between thyroid gland function and idiopathic pulmonary hypertension, finding subclinical hypothyroidism in almost half of patients observed. The study, “Assessment of Thyroid Function in Idiopathic Pulmonary Hypertension,” was published in the Research in Cardiovascular Medicine journal. Idiopathic pulmonary hypertension is a rare and ultimately fatal…

Experimental PH Treatment, Ubenimex, Recognized as Orphan Drug by EMA in Advance of Clinical Study

Eiger BioPharmaceuticals recently announced that its protease inhibitor ubenimex has been granted Orphan Medicinal Product designation by the European Medicines Agency (EMA) for the treatment of pulmonary arterial hypertension (PAH). The company will soon begin a Phase 2 clinical trial testing ubenimex in this patient group. The EMA designation covers…

Pulmonary Rehab of Multiple Benefit to People with PH and Other Respiratory Diseases, Release Notes

Pulmonary rehabilitation has been shown to significantly improve the quality of life of those affected by lung diseases, including chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis (IPF), or pulmonary hypertension (PH), a University of Kentucky news release reported. But what, exactly, is pulmonary rehabilitation? The American Association of…

Actelion’s Uptravi (selexipag) Approved for PAH Patients in Australia and New Zealand

Actelion has announced that its orally active pulmonary arterial hypertension (PAH) drug, Uptravi (selexipag), has been approved for the treatment of PAH patients by both the Therapeutic Goods Administration of Australia and the New Zealand Medicines and Medical Devices Safety Authority. The drug was recently approved by the U.S. Food and Drug Administration (FDA)…

Hemodynamic Exercise Response of PH Patients Seen to Predict Transplant-free Survival Chances

Pulmonary hemodynamic response to exercise can predict the transplant-free survival chances of people with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), according to researchers at the University Hospital Zurich, Switzerland, studying the mean pulmonary arterial pressure to cardiac output (mPAP/CO) relationship during exercise in these patients. The research, titled “Pressure-flow during…