News

Both patients newly diagnosed with pulmonary arterial hypertension (PAH) and animal models of the disease show increased activity of a molecular pathway, known as NNMT-MNA (Nicotinamide N-methyltransferase and 1-methylnicotinamide), which is involved in metabolic and inflammatory reactions. The researchers behind the study, “Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in…

SteadyMed announced that it recently completed the manufacturing of required batches of its drug candidate Trevyent, designed to treat pulmonary arterial hypertension (PAH). The work will allow the company to evaluate the therapy’s shelf-life in advance of submitting a New Drug Application to the U.S. Food and Drug Administration (FDA) early next year.

Patients with pulmonary arterial hypertension (PAH) who fail to benefit from treatment with phosphodiesterase 5 inhibitors (PDE5i) may safely switch to Adempas (riociguat), according to the final results of a clinical trial, which showed that Adempas improved their health. The results were presented at the European Respiratory Society (ERS) International…

An electronic nose, or “e-nose,” that can detect the presence of pulmonary arterial hypertension (PAH) was created by researchers at the Université Paris-Saclay in partnership with the Technion Israel Institute of Technology. The e-nose device makes use of the fact that PAH has a marked olfactory signature, with a specific…

A new study published in the Journal of the American Heart Association reports that, in people with pulmonary hypertension (PH), females, middle-aged patients, and those with chronic diseases have an increased risk of mortality. Most current knowledge comes from small-scale or specialized studies. This is the first Taiwan nationwide…

Patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are successfully treated with pulmonary endarterectomy (PEA) may be at increased risk of having low levels of oxygen in the blood due to severe pulmonary arteriopathy, a condition characterized by pulmonary artery remodeling, according to a study from Chiba University in Japan. The…

Symple Surgical (SSI), a start-up medical device company, announced that it has entered into a development agreement with a confidential partner to advance its microwave ablation technology, for the treatment of hypertension and potentially other conditions, including pulmonary hypertension. The unnamed partner, it said in a press release, has with a long-standing market leadership…

People infected with HIV are known to have a greater incidence of pulmonary hypertension and to be an almost 2,500-fold higher risk of developing PH than others, and a new study looked at HIV-infection and PH rates in Africa, a continent with the highest prevalence of HIV infections worldwide. The study, “Prevalence…

Children born to women with late-stage gestational diabetes — caused by a pregnancy-related, transient increase in blood sugar levels (hyperglycemia) — or to women who are overweight or obese are known to be a higher risk of pulmonary complications, namely respiratory distress and persistent pulmonary hypertension of the newborn (PPHN). While efforts to…

The vascular constrictor coupling factor 6 (CF6) is involved in the development of pulmonary arterial hypertension by creating an imbalance in the inner lining of lung blood vessels, part of larger process known as endothelial dysfunction, according to a recent study by Chinese researchers. The study, “Lung-specific RNA interference of…

Researchers identified two new drugs, both signaling inhibitors, that could aid in the treatment of pulmonary hypertension (PH) by altering vessel stiffness and its downstream control of metabolism. Their work also suggests that a previously unknown link exists between vessel hardening and energy production in the disease. The study, “Vascular…

Karos Pharmaceuticals, a start-up focused on the selective modulation of peripheral serotonin synthesis, recently reported positive results from its Phase 1 clinical trials evaluating KAR5585, a compound being developed to treat orphan diseases such as pulmonary arterial hypertension (PAH) and carcinoid syndrome. KAR5585 is a first-in-class, selective inhibitor of tryptophan hydroxylase…