An updated application has been filed with the U.S. Food and Drug Administration (FDA), again asking that LIQ861 be approved as an inhalation treatment of pulmonary arterial hypertension (PAH), its developer Liquidia announced. The company first made this request in an application to the FDA submitted in April 2020. But the…
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By screening thousands of potential candidates, researchers have identified a compound, called AG1296, that may be useful for the treatment of pulmonary arterial hypertension (PAH). Their findings were published in the journal Science Translational Medicine, in a study, “iPSC–endothelial cell phenotypic drug screening and in silico…
Altavant Sciences has opened ELEVATE 2, its global Phase 2b clinical trial into the safety and efficacy of rodatristat ethyl, a potential disease-modifying oral therapy for people with pulmonary arterial hypertension (PAH). The…
People with mildly elevated pulmonary arterial pressure (PAP) are at higher risk of progression to pulmonary hypertension (PH) than are those with normal readings, according to a review study. These people should be more closely monitored, and further study is needed to understand how best to treat them to…
Note: This article was updated to include information from a Hopkins study published on May 5, 2021, of responses after a second vaccine dose was given to transplant patients. Long before COVID-19 changed the world, organ transplant recipients were wearing masks to shield themselves from airborne threats. Immunosuppressive medicines, which often…
Activation of a protein called aryl hydrocarbon receptor (AHR) is essential for the development of pulmonary arterial hypertension (PAH), a study found. The findings imply that targeting AHR could be a useful strategy to treat PAH, according to researchers. The results were published in the journal PNAS, in…
On May 5, the Pulmonary Hypertension Association (PHA) will join more than 80 organizations around the world in marking World Pulmonary Hypertension (PH) Day and seeking to raise awareness of the rare disease through webinars and on social media. Part of this year’s focus amid the ongoing…
Iron replacement did not affect disease severity or the ability to function in people with pulmonary arterial hypertension (PAH), an analysis of two clinical studies showed. It also was found to have no impact on quality of life for these patients.
Levels of a protein found in certain blood cells indicate the severity and prognosis of pulmonary arterial hypertension (PAH), a study suggested. The findings could help achieve earlier diagnosis of PAH, which may improve clinical outcomes, researchers said. The study, “Circulating nerve growth factor receptor positive…
Claritas Pharmaceuticals has signed a letter of intent with the Salzman Group to acquire exclusive global rights to develop and market R-107 — a liquid form of nitric oxide — to treat, and possibly reverse, pulmonary arterial hypertension (PAH). The agreement is expected to come into effect by May…
More than half of the people with rare diseases and their caregivers, asked in a survey, were undecided or less than willing to be vaccinated for COVID-19 if a vaccine was approved under emergency use authorization instead of the routine process, the EveryLife Foundation for Rare Disease reports. These findings…
United Therapeutics has submitted an application to the U.S. Food and Drug Administration (FDA) seeking approval of Tyvaso DPI, a dry powder inhaled formulation of treprostinil, for both pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD). To expedite the process, the company  applied…
