Researchers Find microRNA Triggers Pulmonary Hypertension in Hypoxia Conditions

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The microRNA miR-214 is mediating lung artery remodeling in response to hypoxia, leading to pulmonary hypertension.

Chinese researchers have identified a microRNA as a key molecular factor involved in lung blood vessel remodeling in response to low oxygen levels — a process leading to pulmonary hypertension.

The study “Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2,” published in the journal Scientific Reports, revealed new insights into the mechanisms leading to lung hypertension that might one day lead the way to better treatments for the devastating disease.

Low oxygen (hypoxia), is a known trigger of lung hypertension — a feared complication for patients with chronic obstructive pulmonary disease (COPD). Among the 30% of COPD patients who develop lung hypertension, airway obstruction and hypoxia are more severe.

Earlier research suggests that microRNAs, RNA molecules not involved in protein production but in the control of gene activity, are key players in the adaptations the body makes when faced with low oxygen levels. Such microRNAs are called “hypoxamiRs.”

To learn more about how hypoxamiRs can contribute to lung hypertension, researchers at the Xijing Hospital at the Fourth Military Medical University, in China, cultured smooth muscle cells isolated from the lung artery of 18 COPD patients with, and 15 COPD patients without hypertension. Screening for hypoxamiRs, researchers found that only miR-214 was increased in patients with hypertension. The increase was also accompanied by lower levels of the protein CCNL2 (cyclin L2) — a factor involved in cell death.

Experiments showed that when researchers added miR-214 to cells in a lab dish, they began to divide faster. The action was made possible by suppression of a process called apoptosis (programmed cell death.) Apoptosis is crucial for keeping cell populations in check, but the research team discovered that miR-214 lowered the levels of the cell death factor CCNL2 that allowed cell death to take place. Repeating the experiment with added blockers of miR-214 prevented cells from expanding, showing that CCNL2 was controlled by miR-214.

The team concluded: “Taken together, the results of our study showed for the first time that the abnormal, hypoxia-induced enhancement of PASMC [pulmonary artery smooth muscle cells] proliferation can be partially but significantly attenuated by the downregulation of miR-214. This finding might shed some light on the molecular mechanism underlying the development of PH in COPD patients, as well as on the prevention and treatment of this complication.”

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Magdalena holds an MSc in Pharmaceutical Bioscience and an interdisciplinary PhD merging the fields of psychiatry, immunology and neuropharmacology. Her previous research focused on metabolic and immunologic changes in psychotic disorders. She is now focusing on science writing, allowing her to culture her passion for medical science and human health.
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