Although many factors are thought to contribute to PAH, more than 15 percent of all patients have heritable pulmonary arterial hypertension caused by one of three things:
- A family history of pulmonary arterial hypertension
- An autosomal dominant genetic condition caused by mutations in the BMPR2 gene or TGFbeta pathway
- Diet drug use (i.e., Fen Phen, Pondimin, Redux, and methamphetamines)
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