Alice Melão, MSc,  —

Bellerophon Therapeutics recently provided an update on the clinical development of INOpulse as a treatment for pulmonary arterial hypertension (PAH), as well as for pulmonary hypertension associated with chronic obstructive pulmonary disease (PH-COPD) and interstitial lung disease (PH-ILD). INOpulse is an inhaled nitric oxide treatment being developed to reduce…

A molecular mechanism involving the tight balance between two proteins — Gal-1 and CaV1.2 — was found to regulate the behavior of blood vessel cells, directly contributing to hypertension. This finding provides new insights into the underlying processes that trigger arterial contraction and hypertension, and its researchers suggest that a…

Horizon 2020, the European Union’s prestigious research and innovation program, recently awarded ATXA Therapeutics €2.5 million ($2.91 million) to support the development of ATXA’s lead therapy candidate NTP42 and help get it to market quicker as a treatment for pulmonary arterial hypertension (PAH). The ATXA research project was…

Scottish patients with pulmonary arterial hypertension (PAH) can now be treated with Actelion‘s Uptravi (selexipag) through the country’s National Health System (NHS) after a positive recommendation from the Scottish Medicines Consortium (SMC). However, the use of this therapy will be restricted to adult patients in WHO functional…

Reata Pharmaceuticals is currently recruiting participants for its Phase 3 CATALYST trial assessing the effectiveness of bardoxolone methyl in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH). After analysis of the Phase 2 LARIAT study (NCT02036970) results in pulmonary hypertension (PH) and interim data of the first 100…

A gene called FoxM1 was seen to be an important regulator of the vascular remodeling process involved in pulmonary hypertension.  It triggers the proliferation of smooth muscle cells in the lung’s blood vessels, which in turn promotes the thickening of artery walls and elevated arterial blood pressure. Inhibiting or blocking FoxM1 activity…

Surgery to repair congenital heart defects leads to longer survival in patients with pulmonary arterial hypertension (PAH) caused by heart disease, according to researchers. This finding was reported in the study, “Contemporary survival of patients with pulmonary arterial hypertension and congenital systemic to pulmonary shunts,” published…

University of Edinburgh researchers identifying a protein that could become a target for treating pulmonary arterial hypertension, or PAH. They discovered that the two-pore segment channel 2 protein, or TPC2, in pulmonary artery muscle cells regulates signals triggered by calcium that are important to controlling muscle cell contractions. The finding offers…

The genetic landscape of pulmonary arterial hypertension that strikes in childhood differs from the one that develops after a person reaches adulthood, a study reports. There is little variation between children and adults in gene mutations commonly associated with PAH, such as BMPR2. But children have more of the rarer…

A protein called KLF15 has an important protective role in the lung, according to the findings of Johns Hopkins researchers. KLF15 was found to be a critical regulator of genes that are necessary for the maintenance of proper lung blood vessels’ function. In addition, the protein was shown to…

Bellerophon Therapeutics is advancing the clinical trials program of its inhaled INOpulse nitric oxide therapy for pulmonary hypertension (PH) associated with several lung diseases. The company is developing INOpulse for patients with pulmonary arterial hypertension (PAH), PH associated with chronic obstructive pulmonary disease (COPD), and PH linked to interstitial lung…

Computer software combined with artificial intelligence can generate advanced imaging techniques for serious diseases such as pulmonary hypertension (PH), improving healthcare, British scientists say. This was the focus of a workshop on digital radiology at Imperial College Academic Health Science Centre (AHSC) that brought together medical researchers, computer scientists, mathematicians…