Marisa Wexler, MS,  senior science writer—

The investigational treatment TX45 may help improve heart function and circulatory health in people with pulmonary hypertension and heart failure with reduced ejection fraction (PH‑HFrEF). That’s according to new early clinical trial data announced by developer Tectonic Therapeutic, which tested a single intravenous (into-the-vein) dose of the therapy…

The advocacy organization Phaware has launched a new mobile app to help people living with pulmonary hypertension (PH) better manage their condition. Called Heart Works – phaware, the app is available on iPhone, Apple Watch, and Android devices — launching just in time for…

The U.S. Food and Drug Administration (FDA) has approved updated prescribing information for Merck‘s Winrevair (sotatercept-csrk) that more specifically details how the pulmonary arterial hypertension (PAH) therapy reduces the risk of serious complications. Winrevair was approved by the FDA last year to improve…

A new experimental therapy for pulmonary arterial hypertension (PAH), called ALG-801, has shown superior efficacy over current standard-of-care treatments in early laboratory studies, according to its developer, Alivegen. In animal testing, the medication reduced signs of the disease by targeting a molecular pathway involved in the abnormal growth…

Worldwide, pulmonary arterial hypertension (PAH) affects more than 2 of every 100,000 females ages 15 to 49 — women and girls of childbearing age —  according to a new analysis of data spanning some three decades. The researchers noted that the rates of PAH vary substantially in different parts…

The PAH Initiative is hosting video events in November to discuss the importance of shared decision making between doctors and patients to help manage pulmonary arterial hypertension (PAH). The hour-long broadcasts, which are intended for adults with PAH and their caregivers, will take place at 8 p.m. EST…

Allrock Bio has raised $50 million in financing to support the clinical development of pulmonary hypertension (PH) treatment ROC-101. The company said it will use the funds to launch a Phase 2a clinical trial to test ROC-101 in people with pulmonary arterial hypertension (PAH) or pulmonary hypertension associated…

Japan’s Ministry of Health, Labour and Welfare (MHLW) has granted orphan drug designation to mosliciguat, an investigational inhalation therapy that Pulmovant is developing to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD). The MHLW gives this designation to experimental medicines intended to treat conditions affecting fewer than…

United Therapeutics and Mannkind Corporation are teaming up to develop a new inhaled therapy for pulmonary hypertension. The two companies worked together to develop Tyvaso DPI, a dry powder formulation that was approved in the U.S. in 2022 to improve exercise ability in people with…

At diagnosis, Black people with pulmonary arterial hypertension (PAH) tend to have more severe disease than their non-Black counterparts, a new U.S. study shows. The study, done using data from the University of Illinois Health Pulmonary Hypertension Clinic, further indicated that Black people being evaluated for PAH also tend…

A study found that changes in immune cell metabolism may underlie increases in inflammatory signaling molecules in people with pulmonary arterial hypertension (PAH), suggesting that targeting immune cell metabolism could be a treatment strategy for the condition. The study, “Metabolic changes of peripheral blood mononuclear cells…

The rates of long-term survival and perioperative complications after a lung transplant in people with group 2 or group 3 pulmonary hypertension (PH) aren’t significantly different from those in people who don’t have PH, a study reports. “No significant differences [between group 2 PH, group 3 PH, or no…