Marisa Wexler, MS,  senior science writer—

Altered activity of a protein called PUM1 plays a key role in the development of pulmonary hypertension (PH), according to a new study done in animal and cell models. “Our study establishes PUM1 as a critical driver of PH pathogenesis [disease development],” the scientists wrote, adding that “this discovery…

Merck Canada has taken what it called a “critical step” toward making its approved therapy Winrevair (sotatercept-csrk) — which works to improve exercise capacity and reduce the risk of clinical worsening events in people with pulmonary arterial hypertension (PAH) — accessible to eligible patients in the country. The…

Merck is planning a Phase 3 trial testing Winrevair (sotatercept-csrk) in people with combined post- and precapillary pulmonary hypertension (CpcPH) due to heart failure with preserved ejection fraction (HFpEF). CpcPH is a form of pulmonary hypertension due to left heart disease, marked by elevated blood pressure in the vessels…

CM5480, an experimental therapy being developed by Calcimedica, improved blood flow and heart-function measures in a rat model of pulmonary arterial hypertension (PAH), a new study reports.  The therapy was helpful when used on its own and provided additional benefits when combined with two currently available…

The investigational treatment TX45 may help improve heart function and circulatory health in people with pulmonary hypertension and heart failure with reduced ejection fraction (PH‑HFrEF). That’s according to new early clinical trial data announced by developer Tectonic Therapeutic, which tested a single intravenous (into-the-vein) dose of the therapy…

The advocacy organization Phaware has launched a new mobile app to help people living with pulmonary hypertension (PH) better manage their condition. Called Heart Works – phaware, the app is available on iPhone, Apple Watch, and Android devices — launching just in time for…

The U.S. Food and Drug Administration (FDA) has approved updated prescribing information for Merck‘s Winrevair (sotatercept-csrk) that more specifically details how the pulmonary arterial hypertension (PAH) therapy reduces the risk of serious complications. Winrevair was approved by the FDA last year to improve…

A new experimental therapy for pulmonary arterial hypertension (PAH), called ALG-801, has shown superior efficacy over current standard-of-care treatments in early laboratory studies, according to its developer, Alivegen. In animal testing, the medication reduced signs of the disease by targeting a molecular pathway involved in the abnormal growth…

Worldwide, pulmonary arterial hypertension (PAH) affects more than 2 of every 100,000 females ages 15 to 49 — women and girls of childbearing age —  according to a new analysis of data spanning some three decades. The researchers noted that the rates of PAH vary substantially in different parts…

The PAH Initiative is hosting video events in November to discuss the importance of shared decision making between doctors and patients to help manage pulmonary arterial hypertension (PAH). The hour-long broadcasts, which are intended for adults with PAH and their caregivers, will take place at 8 p.m. EST…

Allrock Bio has raised $50 million in financing to support the clinical development of pulmonary hypertension (PH) treatment ROC-101. The company said it will use the funds to launch a Phase 2a clinical trial to test ROC-101 in people with pulmonary arterial hypertension (PAH) or pulmonary hypertension associated…

Japan’s Ministry of Health, Labour and Welfare (MHLW) has granted orphan drug designation to mosliciguat, an investigational inhalation therapy that Pulmovant is developing to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD). The MHLW gives this designation to experimental medicines intended to treat conditions affecting fewer than…