Marisa Wexler, MS,  senior science writer—

At diagnosis, Black people with pulmonary arterial hypertension (PAH) tend to have more severe disease than their non-Black counterparts, a new U.S. study shows. The study, done using data from the University of Illinois Health Pulmonary Hypertension Clinic, further indicated that Black people being evaluated for PAH also tend…

A study found that changes in immune cell metabolism may underlie increases in inflammatory signaling molecules in people with pulmonary arterial hypertension (PAH), suggesting that targeting immune cell metabolism could be a treatment strategy for the condition. The study, “Metabolic changes of peripheral blood mononuclear cells…

The rates of long-term survival and perioperative complications after a lung transplant in people with group 2 or group 3 pulmonary hypertension (PH) aren’t significantly different from those in people who don’t have PH, a study reports. “No significant differences [between group 2 PH, group 3 PH, or no…

A Phase 3 clinical trial testing the experimental daily oral treatment ralinepag in people with pulmonary arterial hypertension (PAH) has completed enrollment. The ADVANCE OUTCOMES trial (NCT03626688) enrolled 728 people with PAH who were on oral background therapies. Participants are being randomly assigned to receive ralinepag at doses…

Adding Winrevair (sotatercept-csrk) to background treatment significantly reduces the risk of clinical worsening in people with a recent pulmonary arterial hypertension (PAH) diagnosis, according to results from a Phase 3 clinical trial. The therapy led to “a statistically significant and clinically meaningful reduction in the risk of clinical…

Enrollment is now complete — with nearly 400 participants with pulmonary arterial hypertension (PAH) — in the Phase 3 PROSERA clinical trial that’s testing the PAH treatment candidate seralutinib against a placebo in adults. Top-line results from PROSERA are expected in February 2026, according to Gossamer Bio, which is…

Adding more lines of treatment may reduce the risk of rehospitalization among adults with pulmonary arterial hypertension (PAH) who are taking only one medication, a study reports. “Our results suggest that a shift away from monotherapy towards a greater reliance on combination therapy might help to reduce the risk…

People with pulmonary arterial hypertension (PAH) have abnormalities in their gut microbes that may play a role in their disease, a study reports. Transplanting gut microbes from healthy rats into the digestive tract of a rat model of PAH led to a reduction in disease severity, suggesting that targeting…

Soon after Yutrepia (treprostinil) was approved by the U.S. Food and Drug Administration (FDA) to treat some forms of pulmonary hypertension, the therapy’s maker, Liquidia, scheduled its first commercial shipment to specialty pharmacies. “We have moved with exceptional speed to provide a new and differentiated therapeutic alternative to the…

Plans for a Phase 2b clinical trial that will test CS1, Cereno Scientific‘s experimental treatment for pulmonary arterial hypertension (PAH), have been endorsed by the U.S. Food and Drug Administration (FDA). The FDA’s endorsement comes just a few weeks after a meeting between Cereno and the FDA…

Most people with pulmonary arterial hypertension (PAH) who were treated with Uptravi (selexipag) and followed up for 10 years in an extension study are still alive, according to new data. Adding two other types of PAH therapy or starting triple therapy within six months of a diagnosis…

The first participant has been dosed in a Phase 2 trial testing the experimental oral therapy mirivadelgat in people with pulmonary hypertension associated with interstitial lung disease (PH-ILD). The Phase 2 trial, called WINDWARD (NCT06475781), aims to enroll about 126 adults with PH-ILD, ages 18 to 85. Participants will…