Biopharmaceutical company Pulmokine has entered into a $1 million investment agreement with Broadview Ventures. The partnership is meant to accelerate the development of the lead drug candidate being developed by Pulmokine, PK10571, for the treatment of pulmonary arterial hypertension (PAH) and enable the initiation of its phase 1 clinical trial. The CEO…
Canadian patients who suffer from pulmonary arterial hypertension (PAH) are raising concerns about the risk of heart failure and death associated with the disease due to a new recommendation from the Common Drug Review (CDR) to limit the access of Opsumit (macitentan) to newly diagnosed patients. The alert…
According to a recent study published online in the American Journal of Managed Care, PH-related hospitalizations lead to high healthcare costs, with patients with PAH requiring long hospital stays. The study results also revealed that many patients with PAH are readmitted within 1 year of receiving their…
Clinical stage pharmaceutical company Corbus Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) has approved its investigational new drug (IND) application allowing the company to begin a phase 2 clinical study to evaluate its treatment for diffuse cutaneous systemic sclerosis called Resunab. The phase 2 clinical trial…
Actelion Ltd. will present the latest data from its pivotal phase III trial to evaluate selexipag (Uptravi) for the treatment of pulmonary arterial hypertension (PAH) at the American College of Cardiology (ACC) Congress, which is taking place on March 15 in San Diego. The company…
A recent systematic review titled “Pregnancy and pulmonary arterial hypertension: A clinical conundrum,” highlights that pulmonary arterial hypertension (PAH) is an absolute contraindication for pregnant women. Pulmonary arterial hypertension (PAH) is a rare condition that causes progressive increases in pulmonary arterial pressure and pulmonary…
According to a recent study published in the journal Heart, RV afterload increases in patients with chronic thromboembolic pulmonary hypertension (CTEPH) during exercise, resulting in a marked reduction in RVEF and SV reserve. However, sildenafil may reverse this effect. In patients with…
Results of a new study are shedding light on the emotional and physical impact that IPF has on both patients and caregivers. The new insights could help pave the way for improved patient care, leading to better quality of life for those with the disease. Idiopathic…
Specialty pharmaceutical company SteadyMed Ltd. recently raised $12.2 million in equity financing, co-led by subsidiaries of Federated Investors Inc. and Deerfield Management Company L.P., as well as existing shareholders from the company. The funding will be invested in SteadyMed’s therapeutic product candidates for the treatment of orphan diseases, including…
Researchers at the School of Medicine at Sapienza University of Rome found that Concentric hypertrophy in the heart right ventricle might represent a favorable adaptive pattern to increased afterload in idiopathic pulmonary arterial hypertension. The study, entitled “Right ventricular remodeling in idiopathic pulmonary arterial hypertension: adaptive versus…
Biopharmaceutical company MediciNova recently announced that MN-001 (tipelukast) has been approved for clinical trials by the U.S. Food and Drug Administration (FDA) for the treatment of moderate to severe idiopathic pulmonary fibrosis (IPF). MN-001 is an orally-available small…
Cynata Therapeutics Ltd., an Australian regenerative medicine company developing a therapeutic stem cell platform technology called Cymerus™, has announced the launch of a study to evaluate the platform’s efficacy in treating an animal model of pulmonary fibrosis (PF) — a condition that frequently results in pulmonary…
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