An investigational once-daily therapy, a single tablet combining macitentan and tadalafil, significantly improved pulmonary blood flow compared with macitentan or tadalafil alone in pulmonary arterial hypertension (PAH) patients taking part in the Phase 3 A DUE study. Because these medications target different PAH-related pathways, current guidelines recommend initially treating…
Dozens of medicines with the potential to treat pulmonary arterial hypertension (PAH) patients ill with COVID-19 were identified through computer analyses of the biological processes shared by both conditions, a pilot study reported. Disease-related features common to COVID-19 and PAH included inflammation, fibrosis (tissue scarring), hypoxia (low oxygen), immune responses,…
Genes associated with both pulmonary arterial hypertension (PAH) and metabolic syndrome have been identified using computer software tools, a study reports. Metabolic syndrome, thought to promote PAH, is a cluster of conditions marked by high blood pressure, elevated blood sugar, excess body fat around the waist, and abnormal cholesterol…
Enrollment is now complete in REBUILD, a Phase 3 clinical trial evaluating INOpulse, an investigational treatment for people with pulmonary fibrosis (PF) who are at risk of developing pulmonary hypertension (PH). According to the therapy’s developer, Bellerophon Therapeutics, the trial’s enrollment was completed earlier than expected. As…
Two new biomarkers to assess pulmonary arterial hypertension (PAH) were discovered through large-scale analysis of gene activity profiles using computer software, a study reported. These biomarkers, the activity of the genes PNISR and HNRNPH1, may help diagnose PAH, monitor its progression, or measure responses to therapy. They also may highlight…
The identified cause of pulmonary arterial hypertension (PAH) in patients seen at a specialized care center differed substantially from national registry data, a study revealed. Most care center patients were diagnosed with PAH associated with connective tissue disorders and exposure to toxins, whereas idiopathic PAH (IPAH), of unknown cause,…
Cigarette smoking in men newly diagnosed with pulmonary arterial hypertension (PAH) was associated with a faster time to in-patient hospitalization and death after diagnosis, according to an analysis of the REVEAL study in the U.S. More men smoked than women, and ever-smoking status (someone who has been a cigarette…
Children with episodes of fainting due to pulmonary arterial hypertension (PAH) who respond well to a vasodilator given in a challenge test are likely to have better long-term outcomes than those who respond poorly, a long-term records study suggests. A vasodilator challenge is a test to measure blood pressure in…
A blood test for angiopoietin-2 (Ang-2), a protein associated with forming new blood vessels, may predict treatment outcomes in people with chronic thromboembolic pulmonary hypertension (CTEPH), a study showed. Researchers found that the protein’s level was significantly higher in the bloodstream of patients with this rare form of…
Up to two years of treatment with sotatercept safely maintained gains in heart function and physical abilities in people with pulmonary arterial hypertension (PAH), according to details of the PULSAR study extension phase. Further, participants who were initially assigned a placebo in the Phase 2 controlled trial, and switched…
A protein called LTBP-2 was found to be significantly elevated in people with pulmonary arterial hypertension (PAH), according to a new analysis — and the data suggest that measuring its levels may help predict long-term survival among PAH patients. Further, blood levels of LTBP-2 were also able to predict…
Extracellular vesicles derived from mesenchymal stem cells eased the signs and symptoms of pulmonary hypertension (PH) in a rat model of bronchopulmonary dysplasia (BPD), a study shows. BPD is one of the most common complications in prematurely born infants who need supplemental oxygen and is marked by airway damage…
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