News

Combination Therapy Improves Blood Circulation, Analysis Suggests

Combination therapy — a treatment approach used to target multiple pathways involved in pulmonary arterial hypertension (PAH) — improves hemodynamics (blood flow) in treatment-naïve patients, according to a new pooled analysis of several studies. A measure of the resistance to blood flow, called pulmonary vascular resistance (PVR), decreased significantly…

Inhaled Treatment MK-5475 Shows Promise in Phase 1 Trial for PAH

Merck’s investigational inhaled treatment MK-5475 was well-tolerated and showed promise among adults with pulmonary arterial hypertension (PAH) in a Phase 1 clinical trial. Results showed that the therapy improved blood flow in patients’ lungs, but did not affect blood pressure elsewhere in the body. “The promising pulmonary selectivity and…

Treprostinil Infusion Pump for PAH Is Goal of New Collaboration

Liquidia and Sandoz will collaborate with Mainbridge Health Partners to develop a new subcutaneous or under-the-skin infusion pump for treprostinil — a generic form of Remodulin — for treating people with pulmonary arterial hypertension (PAH). The exclusive rights to promote and market treprostinil injection belong…

Inhaled Seralutinib Shows Potential to Treat PAH in Phase 2 Trial

Treatment with seralutinib (GB002), an inhaled investigational therapy, significantly improved measures of blood pressure in the lungs of people with pulmonary arterial hypertension (PAH) in the Phase 2 TORREY study, meeting the trial’s main goal. Promising effects also were seen on measures of exercise capacity and heart structure, with these…

Study: New Automated Strategy May Improve Peptide Therapy in PAH

Researchers have created an automated way to engineer a more stable peptide-based therapy, which could inform the production of new and improved treatments for diseases like pulmonary arterial hypertension (PAH). The research was led by Yousef Al-Abed, PhD, co-director of the Institute of Bioelectronic Medicine at the Feinstein Institutes for…

Eosinophils Reduce Inflammation, Cell Overgrowth in PH: Study

Immune cells called eosinophils help protect against the progression of pulmonary hypertension (PH) by reducing lung inflammation and regulating the growth of muscle cells around blood vessels, a new study indicates. The study, “Eosinophils Protect Against Pulmonary Hypertension through 14-HDHA and 17-HDHA,” was published in the …

Care Center PAH Causes Differ from National Registry, Study Reveals

The identified cause of pulmonary arterial hypertension (PAH) in patients seen at a specialized care center differed substantially from national registry data, a study revealed. Most care center patients were diagnosed with PAH associated with connective tissue disorders and exposure to toxins, whereas idiopathic PAH (IPAH), of unknown cause,…

Few Liver Problems With Opsumit in PAH Patients: Real-world Data

Real-world use of Opsumit (macitentan) was generally safe, with few liver-related toxicities seen, according to data from two registries largely made up of pulmonary arterial hypertension (PAH) patients. Collective data from the two registries met a requirement from the U.S. Food and Drug Administration (FDA) for additional real-world safety…