Immune-related genes that could serve as potential therapeutic targets for pulmonary arterial hypertension (PAH) were identified in a recent study. Among them was ROCK2, which was found to have increased gene activity in PAH patients’ lung tissue and animal models. Therapeutic molecules to inhibit the ROCK2 protein are already being…
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Triple combination therapy — used to target multiple pathways — improves lung and heart function in pulmonary arterial hypertension (PAH) patients, according to real-world data from a racially diverse group. The combo therapy resulted in a significant easing of disease severity, with no patient classified as high risk. Being…
A heart transplant may resolve the pulmonary hypertension (PH) often found in children with heart failure — the organ’s inability to pump enough blood to meet the body’s needs, a small study found. After the transplant, however, it took longer for blood pressure to normalize in children with congenital…
Four proteins related to a pro-inflammatory signaling molecule called TNF-alpha may serve as biomarkers to predict mortality in adults with pulmonary hypertension (PH) caused by left heart failure, a new study shows. Elevated blood levels of two such proteins, both belonging to the TRAIL family, correlated with most standard…
Beyond Air has been given an innovative technology contract from Vizient for its LungFit PH system, which was approved in the U.S. last year to administer nitric oxide to treat persistent pulmonary hypertension of the newborn (PPHN). “We’re very happy and honored…
Most adults with pulmonary arterial hypertension (PAH) experience no worsening and may even see a reduction in the severity of their symptoms after being on treatment with Uptravi (selexipag) for up to about 1.5 years. That’s according to a new analysis of data from all patients who took…
Researchers have identified three proteins — NID1, C1QTNF1, and CRTAC1 — in the bloodstream of people with pulmonary hypertension (PH) whose presence accurately predicted the failure of the heart’s right ventricle (RV) and related outcomes, a study reports. The proteins may serve as biomarkers to assess disease progression and…
Endotronix has been cleared by U.S. regulators to launch a clinical trial testing its Cordella Sensor, an implanted device that measures the pressure in the blood vessels of the lungs, in people with heart failure that slightly limits their physical activity. The study, given the green light by…
The matrix around the heart’s cells does not shrink and may continue to undergo changes after pulmonary endarterectomy, or PEA, a surgery to remove blood clots from the pulmonary arteries that supply the lungs, a small study found. Researchers suggest that fibrosis, or scarring, may explain why the heart’s size…
The presence of pulmonary hypertension (PH) didn’t increase mortality after a heart transplant, according to a new study. The findings oppose earlier studies that suggested an increased mortality rate among transplant recipients with PH, which was considered a contraindication. A secondary analysis of a large transplant registry with 24…
The gene coding for insulin-like growth factor 1 (IGF1) may be involved in both pulmonary hypertension (PH) and pulmonary fibrosis (PF), offering a potential target for treating both diseases, a study suggests. That’s important because for many people with both PH and PF, a lung transplant may be…
An echocardiogram during pregnancy, particularly at the third trimester, may help in predicting a risk of persistent pulmonary hypertension of the newborn (PPHN), a study from China suggests. Echocardiograms, which measure heart function using sound waves, are noninvasive and widely used in diagnosing pulmonary hypertension (PH) in people,…
