News

Prenatal Echocardiograms May Help Predict PH in Newborns 

When done during pregnancy, an echocardiogram — a noninvasive measurement of heart function that uses sound waves — may help doctors predict pulmonary hypertension in newborns, a study in China suggests. An echocardiogram can show how well the heart’s right ventricle, one of its bottom pumping chambers, will push…

Study Gauges Long-term Survival for PAH Patients on Opsumit

More than half of people with pulmonary arterial hypertension (PAH) who start daily treatment with oral Opsumit (macitentan) are expected to still be alive after nine years on the therapy, according to a new analysis of data from the SERAPHIN clinical trial and its open-label extension. “These analyses…

Pre-surgery Risk Assessments in CTEPH Did Not Foresee Outcomes

Among people with chronic thromboembolic pulmonary hypertension (CTEPH), risk assessments and treatment patterns prior to surgical procedures do not predict outcomes after surgery, a new study from Sweden shows. The results suggest that most CTEPH patients who don’t undergo surgery remain in the same risk category for at least…

ELA32 Gene Therapy Found to Lessen PAH in Animal Study

A gene therapy designed to provide a protein implicated in heart function improvement was found to lessen pulmonary blood vessel remodeling and reduce lung blood pressure in a preclinical study of pulmonary arterial hypertension (PAH). The study, “Apela gene therapy alleviates pulmonary hypertension in rats,” was published in…

4-year-old ‘PHighter’ Earns Courage Award in Scotland

When Zac Gunn was diagnosed with pulmonary hypertension (PH) three years ago, he was in very poor shape. But he rallied, astounding his medical team with his resilience and zest for life. And recently, the 4-year-old, who is awaiting a lung transplant, went on stage to receive the Child…

Vasopressin Found to Ease PH Symptoms in Newborns: Case Series

The use of the hormone vasopressin successfully stabilized symptoms associated with pulmonary hypertension (PH) in newborns, and avoided the need for more invasive treatment approaches in some infants, according to data from 10 cases. “Although our findings are exploratory and further research is needed to establish safety and efficacy,…

Blocking Hyaluronic Acid Halts Progression of PH in Early Study

Hyaluronic acid, a major component of the extracellular matrix that supports cell function, directly contributes to the development of pulmonary hypertension (PH) via pulmonary vascular remodeling, a preclinical study has found. By pharmacologically blocking the production of the substance in a PH mouse model, researchers were able to prevent…