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Scientists Discover New Genes and Signaling Pathways Involved in Severe Lung Disease in Premature Infants

A set of new genes and signaling pathways linked to the development of severe lung disease in premature infants was found by researchers from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago and collaborators. Their study, “Exome sequencing identifies gene variants and…

PH-Targeted Therapies Show Modest-at-Best Benefit in PH Due to Left Heart Disease, Review Study Reports

A large review of clinical trials evaluating whether pulmonary hypertension (PH)-targeted therapies can improve exercise capacity in patients with pulmonary hypertension due to left heart disease (PH-LHD) found varying effectiveness and modest benefit. The findings were reported in the study “Pulmonary hypertension-targeted therapies in heart failure: A systematic…