Posts by: Jose Marques Lopes, PhD

News

A tiny RNA molecule known as microRNA-410 (miR-410) was seen to slow the proliferation of endothelial cells in the lung and ease pulmonary vascular remodeling in a mouse model ... Read more

July 15, 2019July 15, 2019

Left Heart Dysfunction Plays Key Role in Severe PAH, Study Suggests

News, PAH News

Left heart dysfunction may play an important role in severe pulmonary arterial hypertension (PAH), and should be monitored to optimize treatment, according to new research. The study, “Impact of ... Read more

July 1, 2019July 1, 2019

Goal-oriented Sequential Combo Therapy Benefits PAH Patients, Study Says

News, PAH News

Use of sequential combination therapy focused on changes in exercise capacity improves health-related quality of life (HRQoL) in patients with newly diagnosed pulmonary arterial hypertension (PAH), according to a ... Read more

June 19, 2019June 27, 2019

Chloride Channel TMEM16A May Be Therapeutic Target for IPAH, Study Suggests

News, PAH News

Patients with idiopathic pulmonary arterial hypertension (IPAH) have greater levels and activity of a chloride channel known as TMEM16A, which contributes to disease-related changes in pulmonary cells, according to ... Read more

May 24, 2019June 18, 2019

Blood Vessel Changes in the Eyes Linked with Lung Vascular Damage in PAH, Study Finds

News, PAH News, PH News

A type of abnormality in small blood vessels of the eyes, called retinal vascular tortuosity, may provide a non-invasive way to detect alterations in lung circulation in patients with ... Read more

April 5, 2019April 5, 2019

LRP1 Protein Levels Linked to Blood Vessel Remodeling in PH, Study Suggests

News, PAH News, PH News

Increased levels of a protein called LRP1 may lead to blood vessel remodeling in pulmonary hypertension (PH) by causing changes in pulmonary artery cells that favor their proliferation, a ... Read more

March 29, 2019March 29, 2019

Certain Patients with Sarcoidosis-associated PH May Benefit from PH-specific Treatment, Real-world Study Suggests

News, PH News

Patients with sarcoidosis-associated pulmonary hypertension (SAPH) can improve their levels of a key biomarker after receiving specific treatment for PH, which suggests that PH-specific treatment may benefit this patient ... Read more

March 13, 2019March 13, 2019

1st Participant Enrolled in Phase 2 Trial of Levosimendan for PH Patients with Heart Failure

News, PH News

The first participant has been enrolled in a Phase 2 trial testing the investigational therapy levosimendan in pulmonary hypertension (PH) patients with heart failure and preserved ejection fraction (PH-HFpEF). Ejection ... Read more

March 4, 2019March 4, 2019

Children with IPH Have Similar Transplant Survival Rates as Those with Other Indications, Study Says

News, PH News

Children with idiopathic pulmonary hypertension (IPH) who underwent lung or combined heart-lung transplants show similar survival rates to children who underwent these procedures for other indications, according to a ... Read more

February 21, 2019February 27, 2019

Higher Levels of 2 Autoantibodies Could Help Diagnose CTEPH and PAH, Study Suggests

CTEPH News, News, PAH News

Patients with chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) have higher serum levels of antibodies against the EDX2 and PHAX proteins, according to research which suggests ... Read more

Posts by: Jose Marques Lopes, PhD

Jose Marques Lopes, PhD

Small RNA Molecule May Slow Pulmonary Vascular Remodeling to Treat PAH, Study Suggests

Left Heart Dysfunction Plays Key Role in Severe PAH, Study Suggests

Chloride Channel TMEM16A May Be Therapeutic Target for IPAH, Study Suggests

Blood Vessel Changes in the Eyes Linked with Lung Vascular Damage in PAH, Study Finds

LRP1 Protein Levels Linked to Blood Vessel Remodeling in PH, Study Suggests

Certain Patients with Sarcoidosis-associated PH May Benefit from PH-specific Treatment, Real-world Study Suggests

1st Participant Enrolled in Phase 2 Trial of Levosimendan for PH Patients with Heart Failure

Children with IPH Have Similar Transplant Survival Rates as Those with Other Indications, Study Says

Higher Levels of 2 Autoantibodies Could Help Diagnose CTEPH and PAH, Study Suggests

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