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Protein That Regulates Calcium Could Become Target for PAH Therapy, Study Reports
University of Edinburgh researchers identifying a protein that could become a target for treating pulmonary arterial hypertension, or PAH.
They discovered that the two-pore segment channel 2 protein, or TPC2, in pulmonary artery muscle cells regulates signals triggered by calcium that are important to controlling muscle cell contractions.
The finding offers new insight into the mechanisms involved in PAH. And it may open the door to more efficient, targeted therapies for the life-threatening disease, the Scottish team said.
Their study in the journal Science Signaling is titled “mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2.” The research was supported by the British Heart Foundation.
Read more about it here: “Protein That Regulates Calcium Could Become Target for PAH Therapy, Study Reports”
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