A gene called NDRG1 may help drive blood vessel remodeling seen in chronic thromboembolic pulmonary hypertension (CTEPH) by shifting smooth muscle cells toward a scar-forming state, a study found. “NDRG1 and related key gene axes may serve as potential therapeutic targets for CTEPH,” researchers wrote. The study, “Single-cell transcriptomics…
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I lived in a rural area at the time I was diagnosed with pulmonary hypertension (PH). I didn’t meet another PH patient for nearly a year, and even then, we didn’t get to chat because we were both bouncing from one appointment to another. That distance can make an…
While both Winrevair (sotatercept) and prostacyclin therapies are used to treat pulmonary arterial hypertension (PAH), a new study shows the two treatments appear to affect blood flow differently among PAH patients. When people with this rare type of pulmonary hypertension started prostacyclin treatment, resistance to blood flow in the…
Low blood levels of several oxygen‐sensing molecules are found in people with pulmonary arterial hypertension (PAH), and testing for them may be a useful noninvasive tool for helping make a PAH diagnosis, according to a new study. Specifically, levels of a protein subunit known as HIF-1alpha showed strong…
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