A 62-year-old with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) was successfully treated with immunosuppressants and vasodilators, a case study reports. The unusual antibody linked to her disease, called the anticentriole antibody, may also serve as a marker for the use of immunosuppressives in SSc-PAH patients with this antibody. The…
The Phase 2 HELP study testing levosimendan as a potential treatment for pulmonary hypertension (PH) has exceeded its target number and is fully enrolled, Tenax Therapeutics announced. The trial (NCT03541603), testing the potential therapy in PH patients with heart failure…
The number of both new and existing cases of pulmonary arterial hypertension (PAH) in the southwestern U.S. population was found in a recent study to be higher than that reported in the largest U.S. PH registry, called REVEAL, or the Registry to Evaluate Early and Long-term PAH.
Aria CV announced the end of a funding round that will be used to finance a feasibility study of its medical device, the Pulmonary Hypertension System (Aria CV PH System), in people with pulmonary arterial hypertension (PAH) in the U.S. The series B round, which raised $31 million, was led…
A unique bacterial profile in the guts of patients with pulmonary arterial hypertension (PAH) may contribute to the disease and help predict it, a study found. The identification of specific microorganisms may lead to earlier, less invasive diagnoses, as well as new avenues for treatment. The study,…
Mast Therapeutics Inc. announced positive interim results from an ongoing Phase 2a clinical study of its investigational drug AIR001 for the treatment of patients with pulmonary hypertension (PH) associated with heart failure with preserved ejection fraction (HFpEF). Results were presented by the trial’s lead investigator, Marc A. Simon, MD, MS, FACC, in a…
Bayer Pharmaceuticals announced it is terminating a Phase 2 clinical trial evaluating the efficacy and safety of riociguat in patients with pulmonary hypertension (PH) associated with idiopathic interstitial pneumonias. The decision was based on a recommendation from the trial’s Data Monitoring Committee (DMC), and enrolled patients will be monitored closely after treatment cessation, and…
Insmed, Inc., recently announced that three abstracts related to Arikayce, its drug candidate to treat nontuberculous mycobacteria (NTM) lung disease, and one related to its treprostinil prodrug, will be presented at the American Thoracic Society (ATS) 2016 International Conference taking place in San Francisco on May 13–18. The presentations will cover clinical trial findings…
The Pulmonary Hypertension Association (PHA) announced the launch of “PH Care for All,” an initiative to address disparities in the treatment of pulmonary hypertension (PH) among minorities and low-income patients in the United States, and led by 26 highly regarded PH specialists. “With fourteen treatments — which is as many or more…
Praxair, Inc., announced that it has received approval, through a subsidiary, for the sale of its Noxivent brand of inhaled nitric oxide in Canada. Noxivent is indicated for the treatment of newborns, including some born prematurely, suffering respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension (PH). PH in neonates can…
Actelion has announced that its orally active pulmonary arterial hypertension (PAH) drug, Uptravi (selexipag), has been approved for the treatment of PAH patients by both the Therapeutic Goods Administration of Australia and the New Zealand Medicines and Medical Devices Safety Authority. The drug was recently approved by the U.S. Food and Drug Administration (FDA)…
Pulmonary hemodynamic response to exercise can predict the transplant-free survival chances of people with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), according to researchers at the University Hospital Zurich, Switzerland, studying the mean pulmonary arterial pressure to cardiac output (mPAP/CO) relationship during exercise in these patients. The research, titled “Pressure-flow during…
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