Author Archives: Maureen Newman

Bariatric Surgery Improves PAH in Patients with Obesity

Obesity is a prevalent comorbidity of pulmonary arterial hypertension (PAH), according to a recent study that examined the presence of metabolic syndrome in patients with PAH. In fact, a large body of research has examined obesity-related PAH. However, patients with both of…

Targeted Therapeutics Under Investigation For PAH Treatment

In a world where vasodilators rule the landscape of treatments for pulmonary arterial hypertension (PAH), scientific research groups and pharmaceutical companies around the world are working to develop targeted therapeutics that focus on specific cellular pathways that are associated with dysfunction in PAH patients. Within the realm of targeted therapeutics,…

Bayer HealthCare Tests Chemical Libraries for New PAH Treatment

Research scientists at Bayer HealthCare AG in Germany are optimizing a new chemical inhibitor for pulmonary arterial hypertension (PAH) treatment. The team of medicinal chemists generated a library of compounds centered around inhibiting human neutrophil elastase (HNE), a key driver of inflammation in PAH. After generating molecules that successfully inhibited…

Autoantibodies Not Associated With Death in SSc-PAH Patients

A variety of biomarkers are elevated in the serum of patients with systemic sclerosis-pulmonary arterial hypertension (SSc-PAH). Researchers have mostly been studying these markers to determine if they can be used to help diagnose SSc-PAH or if they can serve as targets for new treatments. Alternatively, a study from Northwestern…

Arginine Therapy May Alleviate PH in Thalassemia Patients

The amino acid arginine may contribute to pulmonary hypertension in patients with thalassemia, a disorder that leads to abnormal oxygenation of blood. A team of researchers from the Thalassemia Clinical Research Network conducted a study demonstrating that abnormal release of the enzyme arginase leads to a lack of bioavailable arginine,…

An Exciting Time for Research into CTEPH Discussed in Review Article

Patients with pulmonary hypertension may be surprised to know that the disease can sometimes be accompanied by the complication known as thromboembolic pulmonary hypertension (CTEPH). Pulmonary embolisms are the root cause of CTEPH because a pulmonary embolism (a blood clot in the lungs) that fails to be degraded via thromboembolysis…

Study Shows That Reducing Inflammasome Proteins Reduces PH in Mice

The inflammasome, which is a multi-protein complex that activates inflammatory processes, was shown to play a role in pulmonary hypertension according to a journal article from the Institute for Experimental Medical Research in Oslo University Hospital. Removing a key component of the inflammasome in mice predisposed to pulmonary hypertension were rescued…