Author Archives: Maureen Newman

Actelion Presents Phase III Clinical Data at ATS Conference

Representatives from Actelion Pharmaceuticals Ltd will be presenting data from its Phase III GRIPHON and SERAPHIN studies at the American Thoracic Society (ATS) Conference 2015, held in Denver, Colorado. GRIPHON focused on the investigational drug selexipag (Uptravi®), while SERAPHIN focused on macitentan (Opsumit®). Both were used for patients with pulmonary…

SSc-PH May Show Increase in Damaged Blood Vessel Biomarker EMPs

Tiny biomarkers for pulmonary hypertension in patients with systemic sclerosis (SSc) may be floating around affected individuals’ bloodstreams. Matthew R. Lammi, MD, of Louisiana State University Health Sciences Center in New Orleans is heading a clinical trial to evaluate the presence of endothelial microparticles (EMPs) in SSc patients with…

Right Ventricular Volume Predicts Changes in Clinically-Stable PAH

Although right heart catheterization is an invasive procedure, it can detect changes in right ventricular volume that predict clinical worsening of pulmonary arterial hypertension. A study from the Department of Pulmonary Diseases at VU University Medical Center in Amsterdam, “Signs of Right Ventricular Deterioration in…

Scleroderma-Related PH Treated with Bayer’s Ventavis in Clinical Trial

Bayer is sponsoring a long-term observational clinical trial involving patients with pulmonary hypertension or pulmonary arterial hypertension due to scleroderma. The aim of the study is to determine the efficacy, safety, and tolerability of inhaled Ventavis (iloprost, also known as BAYQ6256) in 160 patients with either idiopathic or familial…

New Clinical Trial Tests Ambrisentan in Preventing SSc-PAH

Treating patients with systemic sclerosis (SSc) who have borderline pulmonary arterial hypertension (PAH) is vital to patient health, as life expectancy after a diagnosis of SSc-PAH is only one year. Accordingly, Heidelberg University, along with GlaxoSmithKline, initiated a clinical trial to investigate “Early Treatment of…

Two Signaling Pathways Implicated in SSc-PAH

Clinicians, scientists, and researchers have acknowledged an association between systemic sclerosis (SSc) and pulmonary arterial hypertension, and have even created the disease category “SSc-PAH,” or SSc-related PAH. This category of PAH is remarkably similar to heritable PAH, yet the basis for the similarity has remained unknown. In an effort…