Author Archives: Patricia Silva PhD

New Software Creates Virtual 3-D Hearts to Help Better Guide Treatment

Scientists at Imperial College London have designed software that creates virtual 3-D versions of patients’ heart motion, helping doctors to determine likely outcomes in patients with pulmonary hypertension (PH) with greater accuracy, and possibly improve their treatment. The technology uses cardiac magnetic resonance imaging (MRI), blood tests, and other clinical observations, according to…

First PAH Patient Being Treated with Ubenimex in Extension of Phase 2 Study

Eiger BioPharmaceuticals recently announced that a first patient has completed the 24-week dosing in the Phase 2 LIBERTY study assessing ubenimex as a therapy for pulmonary arterial hypertension (PAH). That patient is now continuing with treatment in an open-label extension trial. “There has been tremendous enthusiasm in the entire community — patients, families,…

Arena Completes Enrollment of PAH Patients in Ralinepag Phase 2 Study

Arena Pharmaceuticals has completed enrolling patients with pulmonary arterial hypertension (PAH) in its Phase 2 clinical trial evaluating the effectiveness of ralinepag (APD811), the company’s investigational drug for the treatment of PAH. “This marks an important step in the development of ralinepag and is evidence of our strategic focus on…

Antipsychotic Agent with Potential as PAH Treatment Named Orphan Drug by FDA

The U.S. Food and Drug Administration (FDA) has designed Reviva Pharmaceuticals’ RP5063 an Orphan Drug as a potential treatment of pulmonary arterial hypertension (PAH), providing the company with developmental and testing assistance. “We are pleased to receive Orphan Drug Designation for RP5063, which emphasizes the significant need for new mediations for patients…

Early Data Support Oral Anti-Fibrotic Treatment, PBI-4050, for Pulmonary Hypertension

ProMetic Life Sciences recently presented positive preclinical data on its fibrosis-targeting lead candidate, PBI-4050, showing that the drug effectively reduces pulmonary hypertension and right ventricular hypertrophy. The company also presented positive effects of PBI-4050 on cardiovascular biomarkers in patients with metabolic syndrome and type 2 diabetes. The data…

Actelion Reports Its PAH Treatment, Macitentan, Aiding CTEPH Patients in Phase 2 Study

Actelion announced that a Phase 2 clinical trial evaluating its pulmonary hypertension treatment, macitentan, in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) has met its primary endpoint. At week 16, treatment resulted in a significant reduction in pulmonary vascular resistance (PVR) compared to placebo. MERIT is a 24-week, randomized and…